ISRCTN15441965已完成未知
The clinical and cost effectiveness of temporarily quadrupling the dose of inhaled steroid to prevent asthma exacerbations: a pragmatic, randomised, normal care-controlled clinical trial
niversity of Nottingham (UK)0 个研究点目标入组 1,774 人开始时间: 2013年4月25日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 1,774
研究概览
简要总结
2016 protocol in: https://www.ncbi.nlm.nih.gov/pubmed/27737713 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/29504499 2018 results in: https://www.ncbi.nlm.nih.gov/pubmed/30520413
研究设计
- 研究类型
- Interventional
入排标准
- 性别
- All
入选标准
- •1. Male or female aged 16 years and over
- •2. Clinician diagnosed asthma treated with a licensed dose of inhaled corticosteroid (i.e. step 2 to 4 of the British Thoracic Society [BTS] /Scottish Intercollegiate Guidelines Network [SIGN] guidelines)
- •3. One or more exacerbation in the last 12 months requiring treatment with systemic corticosteroids
排除标准
- •Potential participants will be excluded on the basis of:
- •1. History more in keeping with smoking related chronic obstructive pulmonary disease [COPD] (smoked > 20 pack years, without evidence of significant reversibility and eosinophilia)
- •2. On maintenance oral steroids (i.e. step 5 BTS/SIGN guidelines)
- •3. Using a combination inhaler for both maintenance and relief treatment
- •4. Experienced an exacerbation within 4 weeks of randomisation
- •5. Pregnant women, lactating women or women who are planning to become pregnant
研究者
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