Activating the frontal brain in schizophrenia: comparison of aripiprazole versus resperidone using functional magnetic resonance imaging
Completed
- Conditions
- chronic psychosisSchizophrenia10039628
- Registration Number
- NL-OMON31229
- Lead Sponsor
- niversitair Medisch Centrum Groningen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 44
Inclusion Criteria
People diagnozed for schizophrenia according to DSM-IV. They should not repsond to first choiche treatment or suffer from serious side effects.
Besides, healthy control without high education level.
Exclusion Criteria
Subjects with a psychiatric or neurologic disease other than schizophrenia, for which they have been treated. Presence of MRI incompatible implants. For safety reasons female participants who may be pregnant will be excluded.
Study & Design
- Study Type
- Observational invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>Difference in brain activity of the prefrontal cortex between groups with<br /><br>different medication. Besides accuraty and reactiontimes during task<br /><br>performance and severeness of positive and negative symptoms.</p><br>
- Secondary Outcome Measures
Name Time Method <p>nvt</p><br>