Postoperative analgesia with continuous epidural bupivacaine/sufentanil versus bupivacaine/morphine in patients undergoing major surgery.
Phase 4
Completed
- Conditions
- pijnbehandelinganalgesia
- Registration Number
- NL-OMON33682
- Lead Sponsor
- niversitair Medisch Centrum Utrecht
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 530
Inclusion Criteria
All patients > - 18 years old, scheduled for major surgery and indicated for epidural catheter.
Exclusion Criteria
No dutch speaking, mental disability, allergy to one of the study medications. Pregnancy.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>-The pain scores of the patient on the Numerical Rating Scale (NRS) during the<br /><br>first<br /><br>72 hours after surgery.</p><br>
- Secondary Outcome Measures
Name Time Method <p>-Registration of side-effects: pruritus, nausea and vomiting.<br /><br>-Registration of adverse effects: respiratory depression, sedation and motor<br /><br>block.<br /><br>-The quality of pain relief by the patient.</p><br>
Related Research Topics
Explore scientific publications, clinical data analysis, treatment approaches, and expert-compiled information related to the mechanisms and outcomes of this trial. Click any topic for comprehensive research insights.
What molecular mechanisms underlie the analgesic effects of bupivacaine/sufentanil versus bupivacaine/morphine in postoperative pain management?
How does the efficacy of continuous epidural bupivacaine/sufentanil compare to bupivacaine/morphine in major surgical patients' postoperative analgesia?
Are there specific biomarkers that can predict patient response to bupivacaine/sufentanil or bupivacaine/morphine epidural analgesia in major surgery?
What are the potential adverse events associated with continuous epidural bupivacaine/sufentanil versus bupivacaine/morphine in postoperative care?
What alternative analgesic combinations or competitor drugs are being evaluated alongside bupivacaine/sufentanil and bupivacaine/morphine for postoperative pain in major surgery?