Efficacy of Whitfield’s Ointment (3% Salicylic acid + 6% Benzoic acid) with topical Luliconazole vs topical Luliconazole for tinea corporis: A randomized controlled study.
试验速览
- 阶段
- 4 期
- 状态
- 尚未招募
- 发起方
- 入组人数
- 80
- 试验地点
- 1
- 主要终点
- . Whitfields ointment with Topical Luliconazole has better efficacy and better response time as compared to topical luliconazole in treatment of tinea corporis
研究概览
简要总结
Superficial fungal infections of the skin, hair, and nail are among the most common infective dermatoses seen in the dermatology outpatient department. Dermatophytosis refers to a superficial mycotic infection caused by either of the three groups of keratinophilic fungi, namely, Epidermophyton (skin and nails), Trichophyton (skin, nails, hair), Microsporum (skin and hair). These comprise the most common agents responsible for superficial cutaneous fungal infections.
The cases we see in all hospitals are just the tip of the iceberg in the community. Numerous treatment options are available used either as monotherapy, sequential therapy and combination therapy mainly including topical and systemic antifungal drugs.
Whitfield ointment (WO) is an antiseptic ointment that was widely used in the past to treat topical fungal infections. Its efficacy has been shown to be equal to other topical antifungal in several studies conducted. Very few studies have compared its efficacy with topical antifungals . Hence this study will compare efficacy of whitfields ointment against the antifungal therpay being given currently in tinea corporis.
研究设计
- 研究类型
- Interventional
- 分配方式
- Coin toss, Lottery, toss of dice, shuffling cards etc
- 盲法
- Participant Blinded
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •consenting adults who are clinically diagnosed as tinea corporis.
排除标准
- •Patient with superficial dermatophytosis other than tinea corporis.
- •Extensive tinea corporis more than 20% BSA c.
- •Pregnant and lactating mothers e.
- •Patients on any immunosuppressant drugs/immunosuppressive patients f.
- •Any Seropositive patient – HIV, HbsAg , HCV , VDRL g.
- •Patient with history of severe allergy or anaphylaxis.
结局指标
主要结局
. Whitfields ointment with Topical Luliconazole has better efficacy and better response time as compared to topical luliconazole in treatment of tinea corporis
时间窗: both modalities being compared at baseline , 14 days , 28 days.
次要结局
- The disease regression is faster in whitfields ointment with Topical Luliconazole as compared to topical luliconazole.(baseline 14 days & 28 days)
研究者
Dr Soham Virani
kalinga institute of medical sciences