Correlation of Hematological Parameters and MELD score in patients with Alcoholic Liver Disease : Observational study.
试验速览
- 阶段
- 不适用
- 状态
- 尚未招募
- 发起方
- 入组人数
- 100
- 试验地点
- 1
- 主要终点
- To Assess MELD score and MELD group in patients with Alcoholic liver disease
研究概览
简要总结
Alcoholic liver disease (ALD) is a spectrum of liver disorders caused by excessive and prolonged alcohol consumption. It encompasses a range of conditions, including fatty liver, alcoholic hepatitis, cirrhosis and hepatocellular carcinoma. ALD is one of the leading causes of liver related morbidity and mortality worldwide. Abnormalities in hematological parameters and MELD score are associated with increased risk of complications, including bleeding and infection. All these parameters determine a greater extend of mortality and morbidity in these patients. The principle goal is to establish a single score resulting from the sum of subset of individual variables, each being supposed to weigh on the disease progression.
The model for End-Stage liver disease score is a numerical scale developed to assess the severity of liver disease. MELD score incorporates three laboratory values : serum bilirubin, serum creatinine, and international normalized ratio(INR)
MELD Score (Model for End stage Liver Disease Score):
9.6 loge(creatinine mg/dl ) + 3.8 loge(Bilirubin mg/dl) + 11.2 loge (INR) +6.4
By assessing hematological parameters and calculating the MELD score, severity of Alcoholic liver disease can be assessed so, the clinician can make decisions regarding the managment and prognosis of patients with Alcoholic Liver Disease.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18.00 Year(s) 至 65.00 Year(s)（—）
- 性别
- All
入选标准
- •All sample received from OPD and IPD belonging of age more than equal to 18 years and both gender diagnosed with Alcoholic Liver Disease.
排除标准
- •Patients with a known case of primary coagulation disorders, Renal disease, Non Alcoholic Liver Disease, severe Infections and immunocompromised patients.
结局指标
主要结局
To Assess MELD score and MELD group in patients with Alcoholic liver disease
时间窗: 15 Months
To Assess Biochemistry parameters in patients with Alcoholic liver disease
时间窗: 15 Months
To Assess the proportion of Anemia in both gender of patients with Alcoholic Liver Disease
时间窗: 15 Months
To Assess the proportion of Normal Platelet count, thrombocytosis and thrombocytopenia in patients with Alcoholic Liver Disease
时间窗: 15 Months
To Assess the proportion of leukocytosis, leukopenia and normal leukocyte count in patients with Alcoholic liver disease
时间窗: 15 Months
To determine association between hematological parameters and MELD score.
时间窗: 15 Months
次要结局
未报告次要终点
研究者
Dudhat Kinjal
Govt. Medical College, Bhavnagar