Effects of combined diuretic therapy on exercise capacity, alveolar-capillary diffusion and maintenance of euvolemia in chronic congestive heart failure, diuretic therapy compared with loop diuretics and potassium-sparing diuretics

Phase 3

Recruiting

• Conditions: congestive heart failure

• Registration Number: 2024-519565-21-01
• Lead Sponsor: Centro Cardiologico Monzino S.p.A.

Brief Summary

To compare two different treatment strategies (control arm treated with loop diuretic and potassium sparing and experimental arm that will combine such therapy with acetazolamide and free-dose metolazone) in patients with chronic heart failure.

Detailed Description

Not available

Study Timeline

• Study First Posted: 2025-03-11
• Last Update Posted: 2025-03-11

Recruitment & Eligibility

• Status: Ongoing, recruiting
• Sex: Not specified
• Target Recruitment: 44

Inclusion Criteria

written informed consent signed

Age: 18-80

Patients with chronic heart failure (at reduced or preserved ejection fraction)

Patients discharged after hospitalization for acute heart failure (at least second episode of decompensation in the past 12 months)

Patients being treated with loop diuretics at the same or higher dosage of furosemide 40 mg (or equivalent) at the time of admission

Exclusion Criteria

age <18 years or >85 years

patients with severe aortic stenosis

patients with severe renal failure (eGFR<20 ml/min/1.73m2 according to CockroftGault)

patients with severe hyponatremia

Medical therapy for heart failure optimized during hospitalization

Documented current pregnancy and lactating status in women of childbearing potential

Study & Design

• Study Type: Interventional clinical trial of medicinal product
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Evaluate differences in the trend of short- to medium-term re-hospitalizations between chronic heart failure patients treated with standard diuretic therapy (control arm) and combination diuretic therapy (experimental arm)		Evaluate differences in the trend of short- to medium-term re-hospitalizations between chronic heart failure patients treated with standard diuretic therapy (control arm) and combination diuretic therapy (experimental arm)

Trial Locations

Locations (1)

Centro Cardiologico Monzino S.p.A.; 🇮🇹 Milan, Italy

Centro Cardiologico Monzino S.p.A.

🇮🇹Milan, Italy

Pierguseppe Agostoni

Site contact

00390258002586

piergiuseppe.agostoni@cardiologicomonzino.it