The influence of the continuous administration of a stimulants (ephedrine or phenylephrine) into a vein on the stability of the blood flow through the heart and blood vessels after the local anesthetic is injected around the spinal cord in the senior adults
Not Applicable
Completed
- Conditions
- Subarachnoidal anesthesiaSurgery
- Registration Number
- ISRCTN44377602
- Lead Sponsor
- niversity Medical Centre Maribor
- Brief Summary
2019 results in: https://www.ncbi.nlm.nih.gov/pubmed/31711417 (added 15/11/2019)
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- All
- Target Recruitment
- 70
Inclusion Criteria
1. Aged 50 years and over
2. ASA II-III
3. Patients scheduled for lower extremity surgery
Exclusion Criteria
1. Heart failure (known ejection fraction less than 30%)
2. Manifest heart valve disease
3. Arrythmias
4. Ishaemic heart disease
5. Manifest liver disease
6. Kidney disease (serum creatinine more than 120 mmol/L)
7. BMI more than 30
8. Drug abuse (including alcohol)
9. Chronic use of benzodiazepines, opioids or other psychotropic substances
6. Drug abuse (including alcohol)
7. Chronic use of benzodiazepines, opioids or other psychotropic substances
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <br> 1. Blood pressure is measured using oscylometric measurement with an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia<br> 2. Cardiac output is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia<br> 3. Heart rate frequency is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia<br>
- Secondary Outcome Measures
Name Time Method <br> 1. Systemic Vascular Resistance (SSVR) is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia<br> 2. Left Cardiac work (LCSW) is measured using thoracic electrical bioimpedancy using an Aesculon, Osypca Medical, 2011 monitor at baseline for 15 minutes before and 30 minutes after subarachnoidal anaesthesia<br> 3. Potential rescue management is recorded for each patient by the investigator at the anesthetic documentation after subarachnoidal anaesthesia<br>