JPRN-UMIN000037307已完成未知
Exploration of biomarkers to predict clinical improvement of atopic dermatitis in patients treated with dupilumab - B-PAD study
Kyushu University Department of Dermatology, Graduate School of Medical SciencesDepartment of Dermatology, Graduate School of Medical Sciences, Kyushu University0 个研究点目标入组 131 人开始时间: 2019年8月1日最近更新:
适应症
试验速览
- 阶段
- 未知
- 状态
- 已完成
- 发起方
- 入组人数
- 131
研究概览
简要总结
o baseline levels of biomarkers were significantly associated with EASI reduction. There were significant associations of baseline levels of LDH, Soluble IL-2 R, TARC, CCL22, CCL27, and CCL18 with POEM reduction. There were also significant associations of baseline levels of LDH, Soluble IL-2R, and TARC with pruritus-NRS reduction. Moreover, there were significant associations of baseline levels of Soluble IL-2R and TARC with uncomfortable skin-NRS reduction.
研究设计
- 研究类型
- Observational
入排标准
- 年龄范围
- 18years-old 至 70years-old（—）
- 性别
- All
入选标准
- 未提供
排除标准
- •(1) Patients treated with oral immunosuppressive drugs, oral steroid, or phototherapy within 4 weeks before dupilumab administration. (2) Female patients who are breastfeeding, pregnant, or have the possibility of being pregnant. (3) Any other patients who are regarded as unsuitable for this study by the investigators.
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