Using Bedside Ultrasound to Screen for Sarcopenia in Older Adults

Completed

• Conditions: Sarcopenia

• Registration Number: NCT04370912
• Lead Sponsor: University of British Columbia

Brief Summary

The loss of both muscle mass and quality with increasing age is called 'sarcopenia' and is a risk factor for falls, fractures and increased mortality. Sarcopenia is diagnosed with Dual-energy X-ray absorptiometry (DXA) scanning (according to current criteria), but in Canada DXA scans are not approved to screen for this condition. One potential solution is Point of Care Ultrasound (PoCUS), since recent advances have made bedside ultrasound technology readily available as a rapid bedside screening tool.

Detailed Description

Some recent work has examined the possibility of using ultrasound as a measure of both muscle quantity and muscle quantity. Work done by Strasser et al, has shown that ultrasonic measures of muscle thickness in the quadriceps muscle has a highly significant correlation with maximal voluntary contration. Other work done by Miron-Mombiela et al has shown that measures of muscle thickness and echointensity (a measure of muscle quality) also show high correlations with grip strength. These findings (supported by our pilot data, see Pilot Data) and new technological advances in bedside ultrasonic devices suggest that these measures might be a valuable contribution to the process of screening for sarcopenia in older adults. In this proposal, Investigators hypothesize that bedside ultrasound, which is increasingly becoming a mainstream component of the standard physical exam, will be a much more specific and accurate alternative to our current best screening methods.

Basic Information
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Recruitment & Eligibility
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Study & Design
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Trial Locations

Study Timeline

• Study First Submitted: 2020-04-27
• Study First Submitted QC: 2020-04-29
• Study First Posted: 2020-05-01
• Study Start: 2021-09-01
• Primary Completion: 2021-12-31
• Study Completion: 2022-04-01
• Status Verified: 2022-10
• Last Update Submitted: 2022-10-31
• Last Update Posted: 2022-11-02

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 152

Inclusion Criteria

• each subject must be 65 years of age or greater

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Exclusion Criteria

• hemodialysis patients will be excluded, due to excessive fluid shifts with dialysis
• patients using chronic oral corticosteroids will be excluded, due to potential muscle atrophy
• hemiparesis due to a stroke or paresis of the lower limbs will be excluded
• subjects with pitting edema on physical exam (due to liver, renal or heart failure) or patients that are severely dehydrated will be excluded
• patients with myositis, systemic connective tissue disorders, systemic atrophies affecting the central nervous system (CNS) and CNS demyelinating diseases will be excluded

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Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Height in cm	through study completion, an average of 1 year	weight and height will be combined to report BMI in kg/m\^2
Weight in kg	through study completion, an average of 1 year	weight and height will be combined to report BMI in kg/m\^2
US measurement for Sarcopenia	through study completion, an average of 1 year	o establish PoCUS measures (muscle thickness, MT; echointensity, EI) as a new screening test for sarcopenia
Handgrip strength in kg	through study completion, an average of 1 year	Handgrip strength cutoffs for sarcopenia for men and women

Trial Locations

Locations (1)

Vancouver Coastal Health Research Institute, VGH Research Pavilion Room 186; 🇨🇦 Vancouver, British Columbia, Canada