NCT02546037已完成不适用
Pilot Study to Determine the Effect of Different Dialyzer Membranes on Clotting During Haemodiafiltration Treatments in Patients With Chronic Kidney Disease
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 10
- 主要终点
- convective volume exchanged
研究概览
简要总结
Primary Objective:
The purpose of this study is to measure the amount of convection achieved with two different haemodiafilters designed for haemodiafiltration and clotting during haemodiafiltration treatment.
详细描述
This is a prospective observational cohort pilot study of patients under the care of the Royal Free Hospital with chronic kidney disease who have been established on regular thrice weekly haemodiafiltration treatments in a dialysis centre. Information on the study will be disseminated to the Royal Free consultant nephrologists at the dialysis centre with primary responsibility for the individual patient.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Crossover
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 85 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Patients age 18 years and older up to 80 years
- •Under the care of the Royal Free Hospital with chronic kidney disease and established on regular thrice weekly haemodiafiltration.
- •Able to provide written informed consent obtained
排除标准
- •Patients scheduled for a kidney transplant
- •Patients taking concomitant systemic anticoagulants
- •Patients with known prothrombotic or bleeding disorders
- •Patients with abnormal platelet counts
- •Patients unable to provide written informed consent
- •Patients not fulfilling inclusion criteria
结局指标
主要结局
convective volume exchanged
时间窗: day 1
volume of convective exchange achieved during the HDF session
次要结局
- visual coagulation(day 1)
- platelet and coagulation pathway activation(day 1)
- small and middle sized solute clearances(day 1)
研究者
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