Morphological and Molecular Characterization of Tumors of the Aero-digestive Tract in Patients Who Have no Risk Factors Such as Alcohol, Smoking, or Occupation

OBJECTIVES:

Primary

• Characterize, morphologically and molecularly, squamous cell carcinoma of the larynx, pharynx, or oral cavity in patients without high-risk factors, such as alcohol consumption, smoking, or occupation.

Secondary

• Study the impact parameters of morphology, molecular characteristics, and genomics on disease-free survival and overall survival of these patients.
• Study the impact parameters of morphological, molecular, and genomic control in the tumor.
• Assess, in advanced tumors, the risk of heterogeneity of morphological, molecular, and genomic control in the tumor.