NCT00963326已完成不适用
Morphological and Molecular Characterization of Tumors of the Aero-digestive Tract in Patients Who Have no Risk Factors Such as Alcohol, Smoking, or Occupation
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 30
- 试验地点
- 10
- 主要终点
- Tumor response rate by RECIST criteria
研究概览
简要总结
RATIONALE: Studying samples of blood and tumor tissue from patients with cancer in the laboratory may help doctors learn more about changes that occur in DNA and identify biomarkers related to cancer.
PURPOSE: This research study is looking at blood and tissue samples from patients with larynx cancer, pharynx cancer, or oral cavity cancer.
详细描述
OBJECTIVES:
Primary
- Characterize, morphologically and molecularly, squamous cell carcinoma of the larynx, pharynx, or oral cavity in patients without high-risk factors, such as alcohol consumption, smoking, or occupation.
Secondary
- Study the impact parameters of morphology, molecular characteristics, and genomics on disease-free survival and overall survival of these patients.
- Study the impact parameters of morphological, molecular, and genomic control in the tumor.
- Assess, in advanced tumors, the risk of heterogeneity of morphological, molecular, and genomic control in the tumor.
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 15 Years 至 120 Years（Child, Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •DISEASE CHARACTERISTICS:
- •Histologically confirmed squamous cell carcinoma of the larynx, pharynx, or oral cavity
- •No risk factors of alcohol consumption, smoking, or occupational hazards such as asbestos, hydrocarbons, paints, nickel, stone dust, or wood dust.
- •Must be a life-time non-smoker, not a former smoker
- •Measurable disease by RECIST criteria
- •PATIENT CHARACTERISTICS:
- •WHO performance status 0-1
- •No other serious concomitant medical conditions precluding general anesthesia
- •No psychological, familial, social, or geographical reasons that would preclude follow up
- •PRIOR CONCURRENT THERAPY:
- •Not specified
排除标准
- 未提供
结局指标
主要结局
Tumor response rate by RECIST criteria
次要结局
未报告次要终点
研究者
研究点 (10)
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