Endothelial colony forming cells and plasma for in vitro studies of thrombosis in the elderly

Recruiting

• Conditions: unwanted blood clotting; venous thromboembolism; 10064477; 10047079

• Registration Number: NL-OMON56432
• Lead Sponsor: eids Universitair Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 18 June 2024

Recruitment & Eligibility

• Status: Recruiting
• Sex: Not specified
• Target Recruitment: 50

Inclusion Criteria

-patients/volunteers older than 60 years
-diagnosis of VTE 1 year or longer before blood draw

Exclusion Criteria

-active cancer
-symptomatic vascular disease, as defined by the use of platelet aggregation
inhibitors
-severe renal insufficiency (eGFR<30),
-diabetes

Study & Design

• Study Type: Observational invasive
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>-difference in expression of senescence markers in endothelial colony forming<br /><br>cells (ECFCs) from older individuals with versus without a previous unprovoked<br /><br>VTE.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>-difference in abundance of 270 plasma proteins as measured with quantitative<br /><br>mass spectrometry between older individuals with or without a previous VTE<br /><br>-difference in thrombin generation capacity of endothelial colony forming cells<br /><br>(ECFCs) from older individuals with or without previous VTE in an organ on a<br /><br>chip model for thrombosis.</p><br>