NL-OMON53724招募中不适用
Magnesium Supplementation as a Strategy to Reduce Serum Calcification Propensity and Vascular Stiffness in People with Type 2 Diabetes. - Mg-MAC
Amsterdam UMC0 个研究点目标入组 74 人开始时间: 待定最近更新:
试验速览
- 阶段
- 不适用
- 状态
- 招募中
- 发起方
- 入组人数
- 74
研究概览
简要总结
暂无简介。
研究设计
- 研究类型
- Interventional
入排标准
- 年龄范围
- 18 至 99（—）
入选标准
- •age 50-80 years;
- •Diabetes Mellitus Type 2;
- •Presence of a predominantly medial arterial calcification pattern on a
- •previously conducted CT scan of the legs;
- •Carotid-femoral pulse wave velocity higher than 12 meter per seconde;
- •Ability to provide informed consent prior to initiating screening visit
- •procedures.
排除标准
- •Myasthenia Gravis;
- •Use of medications that might interact with magnesium supplements
- •(levothyroxine, osteoporosis medications tiludronate and alendronate, warfarin);
- •Advanced diabetes complications (proliferative retinopathy, disabling
- •polyneuropathy, nephropathy with an estimated glomerular filtration rate
- •(eGFR), calculated with the Jaffé method according to the Chronic Kidney
- •Disease Epidemiology Collaboration equation <15 mL/min/1.73m2 or chronic
- •dialysis, cardiac complications);
- •Uncontrolled hyperthyroidism or active parathyroid disease;
- •Chronic diarrheal disease or inflammatory bowel diseases;
- •Congestive heart failure, bradycardia with a resting heart rate below 60 and
- •systolic blood pressure less than 90 mmHg;
- •Atrial Fibrillation;
- •Previous aortic surgery;
- •Severe hepatic insufficiency;
- •Malignancy or other non-cardiac conditions limiting life expectancy to <3 years;
- •Using food supplements that contain magnesium, or unwilling to stop two weeks
- •before randomization;
- •Mental or legal incapacitation to provide informed consent;
- •Plasma magnesium concentration*>*2.6*mg/dL or < 1.5 mg/dL at screening.
研究者
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