Walking-induced motor fatigability in Multiple Sclerosis: a pilot study on underlying mechanisms and the feasibility of sequential resistance and walking-specific endurance training

Completed

• Conditions: MS; Multiple Sclerosis; 10012303

• Registration Number: NL-OMON44052
• Lead Sponsor: Vrije Universiteit Medisch Centrum

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Last Update Posted: 23 April 2024

Recruitment & Eligibility

• Status: Completed
• Sex: Not specified
• Target Recruitment: 20

Inclusion Criteria

Inclusion criteria
- Definite MS
- Age >= 18
- Complain of early occurring fatigue or reduced walking speed during prolonged walking.
- Able to walk continuously for 12 minutes without walking aids

Exclusion Criteria

Exclusion criteria
- Other medical conditions that affect gait (e.g. amputation).
- Serious comorbidities precluding high-intensity exercise training
- Already participating in a high intensity (>=2 per week), guided exercise protocol.
- Pregnancy, given birth previous 6 months, or active pregnancy wish < 6 months
- Use of (dal)fampridine (i.e. fampyra®).
- Use of heart rate regulating medication (i.e. Beta-blockers)
- MS exacerbation <= 3 months

Study & Design

• Study Type: Interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>Walking-induced motor fatigability, with the central determinant: ankle push<br /><br>off power. </p><br>

Secondary Outcome Measures

Name	Time	Method
<p>Spatiotemporal gait characteristics, energy cost of walking, feasibility<br /><br>outcomes of the pilot intervention and measurement procedures. </p><br>