Study on the intervention and management model of metabolic syndrome with hyperuricemia based on ''state'' identification -- a cross-sectional study of metabolic syndrome with hyperuricemia

Phase 1

• Conditions: hyperuricemia, Metabolic syndrome, Gout

• Registration Number: ITMCTR2022000047
• Lead Sponsor: Guang'anmen Hospital, Chinese Academy of traditional Chinese Medicine

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 20 February 2023

Recruitment & Eligibility

• Status: Pending
• Sex: All
• Target Recruitment: Not specified

Inclusion Criteria

Healthy people: (1) no previous history of diabetes, no hypoglycemic drugs taken or injected, fasting blood glucose < 6.1mmol/l, 2h postprandial blood glucose < 7.8mmol/l. (2) No previous history of hypertension, no antihypertensive drugs, and random blood pressure < 130/85mmhg. (3) No history of hyperlipidemia, no lipid-lowering drugs, fasting TG < 1.7mmol/l, fasting HDL-C = 1.04mmol/l; (4) There was no history of hyperuricemia or gout and family history in the past, and had not taken any drugs to reduce uric acid. At the same time, fasting blood uric acid was < 420umol/l in men and < 360umol/l in women;

Metabolic syndrome: (1) abdominal obesity: Chinese male waist = 90cm, female waist = 85CM; (2) Hyperglycemia: fasting blood glucose = 6.1mmol/l or blood glucose = 7.8mmol/l 2h after glucose load and / or diabetes has been diagnosed and treated; (3) Hypertension: blood pressure = 130/85mmhg and (or) has been confirmed as hypertension and treated; (4) Fasting TG = 1.7mmol/l; (5) Fasting hdl-c<1.04mmol/l; It is sufficient to comply with any three or more of (1) - (5).

Asymptomatic hyperuricemia: fasting serum uric acid = 420 umol/l in males and = 360 umol/l in females; Patients with hyperuricemia caused by other reasons were excluded.

Gout: refer to the gout classification standard jointly proposed by ACR and EULAR in 2015. If the score is = 8, it can be diagnosed.

Gouty nephropathy: patients who have a history of hyperuricemia and exclude secondary hyperuricemia caused by other kidney diseases, blood diseases, tumor radiotherapy, chemotherapy or thiazide diuretics, and have one or more of the following clinical conditions: ? persistent abnormal urine, ? renal function damage, ? uric acid kidney stones, whose renal damage can exclude other causes.

Exclusion Criteria

(1) Patients with moderate to severe cognitive understanding or visual impairment who cannot cooperate to complete treatment and examination; (2) Patients with severe heart, lung, liver, kidney and other important organs and blood system dysfunction; (3) Various infections, acute metabolic disorders, diabetes foot and other serious complications of diabetes; (4) Pregnant or lactating women; (5) Previous or current cancer history or other fatal diseases that may affect short-term survival; (6) Patients participating in other clinical studies.

Study & Design

• Study Type: Observational study
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Blood uric acid;

Secondary Outcome Measures

Name	Time	Method
rea nitrogen;Postprandial blood glucose;Blood creatinine;Urea nitrogen;Low density lipoprotein;cholesterol;triglyceride;High density lipoprotein;Fasting blood glucose;glycosylated hemoglobin;