The Prevalence and Risk Factors of Irritable Bowel Syndrome Among Adults

Completed

• Conditions: Colonic Diseases, Functional; Irritable Bowel Syndrome
• Interventions: Other: ROME IV Criteria

• Registration Number: NCT05340400
• Lead Sponsor: University of Aleppo

Brief Summary

This is a multicenter cross-sectional study on the prevalence of Irritable Bowel Syndrome and the risk factors associated with it. The Rome IV criteria is used for diagnosing IBS. A questionnaire-guided interview will be applied to all subjects.

Detailed Description

: Irritable Bowel Syndrome (IBS) is a common functional bowel disorder characterized by abdominal pain or discomfort associated with defecation or an altered bowel habit. IBS can be divided into four subtypes according to the predominant bowel pattern: diarrhea-predominant (IBS-D), constipation-predominant (IBS-C), and both diarrhea and constipation (IBS-M), and when a stool pattern cannot be categorized under any of the above three patterns (IBS-U).

For clinicians, diagnosis of IBS can be challenging because symptoms can be variable over time, and what makes it a real challenge is the absence of a gold diagnostic standard for this syndrome. That is why experts developed the Rome criteria in 2006, which is constantly revised. The latest update of these criteria was published in 2016 as Rome IV.

Unfortunately, studies have indicated higher rates of psychological comorbidity including suicidal ideation and depression among IBS patients, and a significant reduction in health-related quality of life, this negatively affects the productivity of the individual in society. Epidemiological studies of this syndrome have indicated a greater prevalence among women than men, and adolescents among other age groups.

However, despite these attempts by researchers to determine the prevalence patterns and risk factors for this syndrome, many of them are still not sufficiently defined. Hence, our study came to determine the prevalence and risk factors of Irritable Bowel Syndrome among adults.

Study Timeline

• Study First Submitted: 2022-04-15
• Study First Submitted QC: 2022-04-15
• Study First Posted: 2022-04-22
• Study Start: 2022-04-25
• Primary Completion: 2022-05-25
• Status Verified: 2022-06
• Study Completion: 2022-06-10
• Last Update Submitted: 2022-06-11
• Last Update Posted: 2022-06-14

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 5500

Inclusion Criteria

• Volunteer to participate in the study

Exclusion Criteria

• Poorly-controlled hyperthyroidism
• Poorly-controlled hypothyroidism
• Poorly-controlled hyperparathyroidism
• Liver disease
• Paralysis
• Parasitic diseases (worms ...)
• Celiac disease
• Inflammatory bowel disease (Crohn's disease or Ulcerative colitis)
• Lactose intolerance
• Cancer or tumor in the digestive tract

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Arm && Interventions

Group	Intervention	Description
Patients not diagnosed with IBS	ROME IV Criteria	Collaborators will use Rome IV criteria for diagnosing IBS, and then divide participants into those with and without the disease.
Patients diagnosed with IBS	ROME IV Criteria	Collaborators will use Rome IV criteria for diagnosing IBS, and then divide participants into those with and without the disease.

Primary Outcome Measures

Name	Time	Method
The Prevalence of Irritable Bowel Syndrome	30 days	Collaborators will make an interview questions using ROME IV to diagnose IBS among adults.

Secondary Outcome Measures

Name	Time	Method
Perceived Stress Scale as risk factor for IBS	30 days	It is the most widely used measure of global perceived stress, and a robust predictor of health and disease. The total score is calculated on the basis of the answers to a series of questions based on monthly stress, and the participant's health status. PSS is a summary measure of ten items (range 0-4 points for every item). It is classified into low (PSS 0-13), moderate (PSS 14-26), and high perceived stress (PSS 27-40).
Diet and weight questions as risk factor for IBS	30 days	Collaborators will use a questionnaire to determine the participant's predominant dietary pattern, feeding patterns and allergies
Physical activity as risk factor for IBS	30 days	Collaborators will use the World Health Organization questionnaire to classify the physical activity of the participants into good and poor physical activity.
Fatigue as risk factor for IBS	30 days	Fatigue will be measured using the Chalder Fatigue Scale (CFQ), a self-administered questionnaire for measuring the extent and severity of fatigue within both clinical and non-clinical, epidemiological populations. CFQ is a summary measure of eleven items (range 0-33)
Habits as risk factor for IBS	30 days	Smoking, drinking alcohol, caffeine intake, and sleep pattern.

Trial Locations

Locations (2)

Ahmad Yamen Arnaout; 🇸🇾 Aleppo, Syrian Arab Republic

University of Aleppo; 🇸🇾 Aleppo, Syrian Arab Republic