Efficacy and safety of intermittent bolus comparing with traditional continuous drip of 3% NaCl in patients with severe symptomatic hyponatremia at Kranuan Crown Prince Hospital.
- Conditions
- Pateints with Severe symptomatic hyponatremia.Severe symptomatic hyponatremia
- Registration Number
- TCTR20240716002
- Lead Sponsor
- Orakan Lanwong
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Recruiting
- Sex
- All
- Target Recruitment
- 42
1.Patients who are visitting at Emergency room or admitted in Kranuan Crown Prince hospital.
2.Age older than 18 years old.
3.Glucose-corrected plasma sodium less than 125 mmol per L.
4.Severe symptoms (vomiting, drowsy, seizure and coma).
5.Body weight more than or equal 45 kg.
1.Hypotension (systolic blood pressure less than 90 mmol per L) or mean arterial pressure less than 70 mmol per L.
2.Pregnancy or breast feeding.
3.Previous history of volume overload or congestive heart failure (CHF).
4.Patients with lung congestion from chest X-ray.
5.Chronic kidney disease with edema.
6.Cirrhosis with edema.
7.Patients with symptoms of CAD, VHD and arrythmia.
8.Patients with brain injuries or increased intracranial pressure that is not from hyponatremia.
9.Patients who have critical illness suc as respiratory failure,sepsis or multiorgan failure
10.Deny consent form.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Time to achieve target in pNa and improvement of Glasglow Coma Scale (GCS). at 6 hours after treatment minutes
- Secondary Outcome Measures
Name Time Method Changes in pNa 6 hr after treatment mEq/L ,overcorrection rate in 24th and 48 th hr percent,Osmotic demyelination rate 48 hr percent ,mortality rate 30 days percent