In Line Aerosol Nebulization With High Flow
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 40
- 试验地点
- 2
- 主要终点
- Maximal decrease in SpO2 during nebulization with jet nebulizer vs. inline via HFNC compared to the baseline SpO2 values prior to the nebulization therapy
研究概览
简要总结
The objective of ILAN is to assess the safety, feasibility and bronchodilator efficacy of in-line bronchodilator nebulizer delivery with VMN via HFNC system in hypoxemic respiratory failure patients treated with bronchodilators and compare this method to standard-nebulization using a jet nebulizer with a facial mask. The investigators hypothesized that aerosol nebulization using HFNC/VMN represents safer and more convenient approach in hypoxemic respiratory failure patients in comparison to conventional therapy while providing similar bronchodilator efficacy.
详细描述
Objective: To evaluate the safety and feasibility of a novel approach to nebulization treatment via the nasal route in patients with severe hypoxemic respiratory failure dependent on high flow oxygen.
Hypothesis: In-line vibrating mesh nebulizer delivery via HFNC systems is a safe, feasible and efficacious approach in comparison to traditional jet nebulizer delivered nebulization in hypoxemic respiratory failure patients whose usual care includes nebulized drugs.
Specific Aims:
- To evaluate the safety and feasibility of administering vibrating mesh nebulizer-delivered therapy in patients with acute hypoxemic respiratory failure requiring high flow nasal cannula.
- To evaluate the effect of trans-nasal nebulization on patient comfort and satisfaction with therapy in comparison with standard jet nebulization.
- To evaluate differences in resource utilization between patients receiving standard jet nebulization and ILAN with HF, including time spent at the bedside by the respiratory therapist (RT) for delivery of the medication and any additional time gathering setting up and cleaning.
- To evaluate patient and therapist perceptions and preference on the various delivery methods of aerosol delivery.
Study Design: ILAN is a double-crossover, multi-center trial evaluating the safety and feasibility of in line nebulized medication with high flow nasal canula in comparison to standard jet nebulizer therapy in acute respiratory failure requiring the utilization of high flow nasal cannula.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Adults ≥ 18 years of age
- •Patients with mild or moderate hypoxemic respiratory failure (with or without acute hypercapnic respiratory failure) treated with HFNC.
- •Nebulizer therapy ordered by the primary team with at least one dose delivered prior to the enrollment into the study
- •Patients must be on ordered nebulized albuterol, levalbuterol, ipratropium or ipratropium/albuterol combination with a maximum of Q3 or a minimum of Q6 hour frequencies.
- •For Respiratory Therapists: They must be employees of SMICU or RRMC.
排除标准
- •Lack of hypoxemia defined as SpO2> 92% on room air
- •Severe hypoxemia defined by PaO2/FiO2<100 or SpO2<92% on HFNC settings: ≥ FiO2 80% or higher and O2 flow 40L/min
- •HFNC O2 delivery via tracheostomy
- •COVID-19 positive status (within 3 weeks prior to the enrollment)
- •Respiratory distress, defined by respiratory rate > 24 breath per minute
- •Hemodynamic instability defined by the use of two or more vasopressor medications
- •Presence of nasal obstruction that may pose a risk for inadequate nebulizer delivery in the opinion of the investigator
- •Pulmonary comorbidities that, in the opinion of the investigator or clinical team, can pose a risk to subject safety or interfere with the subject's ability to complete the study procedures.
- •Moribund patient not expected to survive >24 hours
- •Inability to obtain informed consent from patient
- •Respiratory therapists who are unwilling to participate.
研究组 & 干预措施
Path A (vibrating mesh nebulizer (VMN) with the high flow nasal cannula)
Enrolled patients will receive two standard forms of inhaled medications as ordered by the physician. Patients will be randomized into two paths of the cross over study. There will be no blinding involved in this randomization. Path A will have medications delivered trans-nasally in line via the vibrating mesh nebulizer (VMN) with the high flow nasal cannula followed by standard jet nebulization (SJN) with face mask at the next time of medication dosing 3-6 hours later.
干预措施: nebulizer via in-line drug delivery maintaining high-flow nasal cannula oxygen (Device)
Path A (vibrating mesh nebulizer (VMN) with the high flow nasal cannula)
Enrolled patients will receive two standard forms of inhaled medications as ordered by the physician. Patients will be randomized into two paths of the cross over study. There will be no blinding involved in this randomization. Path A will have medications delivered trans-nasally in line via the vibrating mesh nebulizer (VMN) with the high flow nasal cannula followed by standard jet nebulization (SJN) with face mask at the next time of medication dosing 3-6 hours later.
干预措施: standard jet nebulization (SJN) with face mask (Device)
Path B (standard jet nebulization (SJN) with face mask)
Path B will receive standard jet nebulization without HFNC followed by the trans-nasal in line nebulization via the HFNC. Patients agreed to enroll in day 2 of the trial will have their clinical path alternated in attempt to control for diurnal variability. All patients will also receive as-needed nebulized treatments as well as usual supportive care provided by respiratory therapists. As needed therapy will be delivered via the method of the current arm of the study they are in, and the washout period will subsequently reset.
干预措施: nebulizer via in-line drug delivery maintaining high-flow nasal cannula oxygen (Device)
Path B (standard jet nebulization (SJN) with face mask)
Path B will receive standard jet nebulization without HFNC followed by the trans-nasal in line nebulization via the HFNC. Patients agreed to enroll in day 2 of the trial will have their clinical path alternated in attempt to control for diurnal variability. All patients will also receive as-needed nebulized treatments as well as usual supportive care provided by respiratory therapists. As needed therapy will be delivered via the method of the current arm of the study they are in, and the washout period will subsequently reset.
干预措施: standard jet nebulization (SJN) with face mask (Device)
结局指标
主要结局
Maximal decrease in SpO2 during nebulization with jet nebulizer vs. inline via HFNC compared to the baseline SpO2 values prior to the nebulization therapy
时间窗: up to 48 hours
Primary Outcome
次要结局
- Duration of hypoxemic episodes with SpO2<88% during the nebulization delivery(up to 48 hours)
- Proportion of patients with documented hypoxemia (<88%) during the nebulization(up to 48 hours)
- ROX score(up to 48 hours)
- Requirement for additional interventions to maintain patient's safety during the nebulization(up to 48 hours)
- Change in respiratory rate during nebulization compared to the baseline rate(up to 48 hours)
- Nosebleed within 2 hours of nebulizer delivery(up to 48 hours)
- Lowest absolute desaturation from the beginning until completion of nebulizer treatment compared to the baseline SpO2 values defined as the lowest adequately measured SpO2 within two minutes prior to the nebulization(up to 48 hours)
- Increase in respiratory rate from the baseline during the nebulization by >10%(up to 48 hours)
- Need to increase O2 support after the nebulization therapy to maintain SpO2>88%(up to 48 hours)
研究者
Igor Barjaktarevic, MD, PhD
Associate Professor
University of California, Los Angeles