Effects of adjunctive Mononitrate, a nitric oxide donor, in outpatients with a Schizophrenia diagnosis

Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP0 个研究点开始时间: 2018年2月1日最近更新: 2023年5月29日

适应症

试验速览

暂无简介。

•Patients of both sexes, age between 18 and 50 years, diagnosis of schizophrenia, in outpatient antipsychotic treatment without modifications in the last month and with symptoms present in the positive or negative dimensions.

•Presence of relevant medical condition, such as cardiovascular diseases, severe hypertension, renal failure, liver disease, hypothyroidism, hyponatremia, B12 hypovitaminosis, previous intracranial hypertension, epilepsy, pregnancy, breastfeeding). This also includes patients who have signs and symptoms suggestive of hypotension such as blurred vision, dizziness, pallor, and cold extremities. History of hypersensitivity to organic nitrates. Diagnosis of substance use disorder according to DSM criteria, except nicotine. Patients with severe psychiatric comorbidities and who are the focus of clinical care in the recruitment period, such as major depressive episode and obsessive compulsive disorder. Patients with clinical criteria for integral hospitalization.

发起方

Hospital das Clínicas da Faculdade de Medicina de Ribeirão Preto - USP