Comparison of two different techniques of general anesthesia drugs administration for development of postoperative lung complications in oral cancer resection surgery with flap reconstruction.
Not Applicable
- Conditions
- Health Condition 1: C01- Malignant neoplasm of base of tongueHealth Condition 2: C001- Malignant neoplasm of external lower lipHealth Condition 3: C04- Malignant neoplasm of floor of mouthHealth Condition 4: C03- Malignant neoplasm of gumHealth Condition 5: C06- Malignant neoplasm of other and unspecified parts of mouth
- Registration Number
- CTRI/2019/09/021345
- Lead Sponsor
- DR BRAIRCH AIIMS NEW DELHI
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- ot Yet Recruiting
- Sex
- Not specified
- Target Recruitment
- 0
Inclusion Criteria
1. Patients undergoing surgery for elective resection of oral cavity tumor resection with Pectoralis major myocutaneous (PMMC) flap reconstruction.
2. BODY MASS INDEX 18.5- 29.9.
3. ASA PS I, II, III.
Exclusion Criteria
1.Patient refusal.
2.Planned for awake intubation.
3.Planned for central arch resection.
4.Planned for tracheostomy.
5.Emergency exploration.
8.Allergy to Propofol or any study drugs.
9.Ejection fraction <45%, right wall motion abnormality (RWMA), arrhythmia, conduction block.
10.Chronic kidney and liver disease.
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method To detect the difference in incidence of postoperative pulmonary complications.Timepoint: over fifth postoperative day.
- Secondary Outcome Measures
Name Time Method 1.To detect the difference in perioperative systemic inflammation: change between preoperative and postoperative Neutrophil Lymphocyte ratio (NLR), Platelet Lymphocyte ratio (PLR) and modified Glasgow Prognostic Score (m GPS). <br/ ><br>2.To detect the change in 24 hour opioid consumption between two groups. <br/ ><br>3.To detect intraoperative side effects, i.e.: hypoxia, hypotension, bradycardia.Timepoint: 1. NLR, PLR and the m GPS scoring will be done day before surgery, at the end of surgery and on postoperative day 1. <br/ ><br>2. Opioids consumption will be assessed for 24 hours. <br/ ><br>3. The side effects will be assessed intraoperatively.