Transdermal administration of morphine to the patients with pai
Not Applicable
- Conditions
- Patients with pain
- Registration Number
- JPRN-UMIN000002027
- Lead Sponsor
- Department of Clinical Pharmacology and Therapeutics
- Brief Summary
Morphine was absorbed systemically. The plasma morphine concentrations gradually increased in a time-dependent manner. The area under the concentration-time curve from 0 to 72 hours values for morphine, morphine-6-glucuronide, and morphine-3-glucuronide were 60.4, 133.7, and 861.5 ngh/mL, respectively.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- All
- Target Recruitment
- 20
Inclusion Criteria
Not provided
Exclusion Criteria
1) Patients with severe respiratory disorder 2) Patients with bronchial asthma attack 3) Patients with severe liver dysfunction 4) Patients with heart failure associated with chronic lung disease 5) Patients with alcohol abuse 6) Patients susceptible with alkaloid
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Pharmacokinetics of transdermal morphine
- Secondary Outcome Measures
Name Time Method