NL-OMON32474
Recruiting
Not Applicable
Structural and functional connectivity in relation to cognitive and social functioning of children with Neurofibromatosis Type 1 - Brain-behavior relationships in NF1
niversiteit Leiden0 sites50 target enrollmentTBD
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Von Recklinghausen's Disease
- Sponsor
- niversiteit Leiden
- Enrollment
- 50
- Status
- Recruiting
- Last Updated
- last year
Overview
Brief Summary
No summary available.
Investigators
Eligibility Criteria
Inclusion Criteria
- •General inclusion criteria: age between 9 and 13 at time of study; Dutch speaking and signed informed consent from parents and participants. NF1 participants fulfill the diagnostic criteria specified by the National Institutes of Health Consensus Conference (National Institutes of Health, 1988\), i.e. they meet two or more of the following criteria: six or more café\-au\-lait spots, two or more neurofibromas, skinfold freckling, an optic glioma, two or more Lisch nodules, or a first degree relative with NF1\.
Exclusion Criteria
- •\-history of psychiatric illness (other than ADHD), closed\-head injury, endocrinological dysfunction, or neurological illness (other than NF1\). Use of psychotropic medication (other than stimulants to treat ADHD\-symptomatology). Many individuals with NF1 receive an ADHD\-diagnosis (there are reports of an ADHD\-incidence of up to 40\-50% in NF1\). Most of them will receive stimulant medication. Because of the high incidence we will not exclude individuals with an ADHD\-diagnosis. Instead, we will control for ADHD and use of stimulant medication in our analyses.
- •\-contraindications for fMRI
- •\-premature birth
Outcomes
Primary Outcomes
Not specified
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