Antihypertensive Efficacy of the Losartan/Hydrochlorothiazide Combination and its Effect on Plasma B-Type Natriuretic Peptide in Hypertensive Patients Uncontrolled by Angiotensin 2 Type 1 Receptor Antagonist Based Therapy
Phase 4
- Conditions
- Hypertension
- Registration Number
- JPRN-UMIN000007101
- Lead Sponsor
- Southern Heart Conference
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Complete: follow-up complete
- Sex
- Male
- Target Recruitment
- 200
Inclusion Criteria
Not provided
Exclusion Criteria
1) Patients with secondary hypertension 2) Patients with cardiac insufficiency (more than NYHA grade II) 3) Patients under treatment with thiazide diuretic 4) Pregnant patients including one trying to conceive pregnancy during the planned study period 5) Patients with severe liver dysfunction 6) Patients with renal failure (serum creatinine ≥2.0 mg/dL) 7) Patients with a history of hypersensitivity to ingredients of losartan and hydrochlorothiazide 8) Patients with a history of hypersensitivity to thiazide or thiazide-like diuretics 9) Patients who are considered not eligible for the study by the attending doctor due to medical reasons
Study & Design
- Study Type
- Observational
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Change and % change in BNP after 12 months of treatment
- Secondary Outcome Measures
Name Time Method Change and % change in blood pressure after 1,2,3,6,9,12,18,24,30 and 36 months of treatment Change and % change in Uric acid, HbA1c, HDL-C, BNP (excluding values at 12 months), Echocardiography, Electrocardiogram after 3,12,24,30 and 36 months of treatment