Q-fever Fatigue Syndrome (QFS) - a relation with upper respiratory tract infections?

Completed

Conditions: Chronische vermoeidheid
Chronic Fatigue
Q fever Fatigue Syndrome
10004018

Registration Number: NL-OMON42875

Lead Sponsor: Radboud Universitair Medisch Centrum

Brief Summary: Not available

Detailed Description: Not available

Recruitment & Eligibility

Status: Completed

Sex: Not specified

Target Recruitment: 30

Inclusion Criteria

QFS patients (n = 10 - 15)
- Meet the LCI guideline on QFS criteria for QFS
- Age >= 18
- Self report of frequent upper respiratory tract infections on outpatient clinic (>= 3 upper respiratory tract infections a year).;Healthy individuals (n = 10-15)
- Age >= 18

Exclusion Criteria

QFS patients (n = 10 - 15)
- No use of immune suppressive medication in the past 3 months;Healthy individuals (n = 10-15)
- No past Q-fever infection (serology)
- No chronic Q-fever
- No Q-fever vaccination
- No use of immune suppressive medication in the past 3 months

Study & Design

Study Type: Observational invasive

Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
<p>1. Cytokine concentrations of monocytes ( from healthy blood donors) that were<br /><br>trained with C. burnetii and re-stimulated with several viral particles, and of<br /><br>monocytes, from QFS patients, that were stimulated with several viral particles.<br /><br>2. Histone modifications surrounding the promoter regions of set cytokines,<br /><br>after training with C. burnetii in healthy blood donors and in QFS patients.</p><br>

Secondary Outcome Measures

Name	Time	Method
<p>3. Outcomes of SIP and CIS questionnaires on limitations and fatigue, related<br /><br>to cytokine concentrations and histone modifications.<br /><br>4. Clinical description of complaints / symptoms of QFS patients.</p><br>