跳至主要内容
临床试验/NCT00393289
NCT00393289已完成不适用

Calcium Absorption and Retention From Marine Products

University of Copenhagen2 个研究点 分布在 1 个国家目标入组 12 人开始时间: 2005年11月最近更新:
适应症

试验速览

阶段
不适用
状态
已完成
入组人数
12
试验地点
2
主要终点
Whole body retention of calcium

研究概览

简要总结

The purpose of the study is to determine the uptake of calcium from fish bone meal from salmon and cod in 12 healthy volunteers. A test meal labelled with trace amounts of a radioactive calcium isotope (Ca47) will be given after an overnight fast and whole body retention of calcium will be measured on day 13, 21, and 24 after the test meal day.

详细描述

Background:

Up till now little attention has been given the exploitation of marine by-products from the fishing industry. Calcium in fish is found mainly in bone and skin. By-products from these sources are limited to production of gelatine. Small fish, which can be eaten whole with bones included, are traditionally considered to be a good source of calcium. Until recently, bioavailability of this calcium was not known. Two recent studies from Denmark have shown that the absorption of calcium from small soft-boned fish was comparable to that of skimmed milk both in rats and in humans.

Calcium fortified foods are likely to play an important role in helping consumers to achieve calcium requirements aimed at reducing the risk of developing osteoporosis. Experimental evidence show a positive effect of calcium supplementation on bone mineral accretion in children, and combined calcium and vitamin D supplementation has resulted in reduced bone loss and fracture incidence in older men and women.

This protocol describes a project on the nutritional utilisation of calcium from fish bone waste. The main objective is to maximise the use and the added value of marine by-products with special emphasis on utilisation of fish bone as a calcium source and determine its bioavailabiliy in humans.

Study design :

研究设计

研究类型
Interventional
分配方式
Randomized
干预模型
Crossover
主要目的
Basic Science
盲法
Quadruple (Participant, Care Provider, Investigator, Outcomes Assessor)

入排标准

年龄范围
18 Years 至 40 Years(Adult)
性别
Male
接受健康志愿者

入选标准

  • healthy males
  • BMI: 18-18 kg/m2
  • age: 18-40 years

排除标准

  • elite athletes
  • on medication
  • gastrointestinal disorders, chronic diseaes
  • prior participation in radioisotpe studies

结局指标

主要结局

Whole body retention of calcium

次要结局

  • D-vitamin and PTH status, serum calcium and phosporus, and calcium intake

研究者

申办方类型
Other
责任方
Principal Investigator
主要研究者

Arne Astrup

Professor

University of Copenhagen

研究点 (2)

Loading locations...

相似试验