Clinical, Molecular and Metabolic Characteristics of Parkinson's Disease (PD) Patients With Parkin Mutation
Not Applicable
- Conditions
- Parkinson's Disease
- Registration Number
- NCT00169364
- Lead Sponsor
- Groupe Hospitalier Pitie-Salpetriere
- Brief Summary
Parkinson's disease is a frequent neurodegenerative disorder. Genetic forms of the disease have been recently identified. The monogenic form due to parkin mutation is responsible for many familial cases and sporadic forms. However, the relationship between the mutation and the genotype of patients is not fully established. The aim of this study is to compare clinical, metabolic and neuropsychological characteristics obtained in patients with parkin mutation with those of patients without parkin mutation.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- UNKNOWN
- Sex
- All
- Target Recruitment
- 50
Inclusion Criteria
- Juvenile Parkinson's disease (< 45 years)
- Parkin mutation
- Normal brain magnetic resonance imaging (MRI)
Exclusion Criteria
- Contraindication to brain MRI
- Women without effective contraception
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Parkin mutation Motor disability Neuropsychological evaluation Psychiatric evaluation
- Secondary Outcome Measures
Name Time Method Positron emission tomography
Trial Locations
- Locations (1)
Centre d'Investigation Clinique-Hôpital Pitié-Salpetriere
🇫🇷Paris, France