Impact of CO2 on Cerebral Blood Flow in Infants Less Than 6 Months During General Anaesthesia
Not Applicable
Completed
- Conditions
- Anesthesia, GeneralInfant
- Interventions
- Procedure: EtCO2 modification
- Registration Number
- NCT03567031
- Lead Sponsor
- St. Justine's Hospital
- Brief Summary
The study aims at assessing cerebral blood flow variations following expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia.
- Detailed Description
The study aims at assessing cerebral blood flow (measured with Near-Infrared Reflectance Spectroscopy - NIRS - and transcranial Doppler - DTC) variations following end-tidal expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia performed according to standards of care.
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 60
Inclusion Criteria
- Age < or = 6 months
- ASA class < or = 3
- General anesthesia required for surgery
Exclusion Criteria
- No parental consent
- Emergency surgery
- Preexisting neurological condition
- Hemodynamic instability
- Preexisting hypoxemia and/or hypercapnia
- Laparoscopy or thoracoscopy, if expected EtCO2 level achieving would require unsafe ventilation parameters
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- SINGLE_GROUP
- Arm && Interventions
Group Intervention Description Main Arm EtCO2 modification In each patient, under ongoing standard general anesthesia in a stable state, EtCO2 is manually modified to reach predefined values, and after waiting until cerebral blood flow has reached steady state, NIRS and DTC values are noted.
- Primary Outcome Measures
Name Time Method NIRS variation 5 to 10 minutes Near-Infrared Spectroscopy value variation after EtCO2 modification
- Secondary Outcome Measures
Name Time Method DTC variation 5 to 10 minutes Transcranial Doppler values variation after EtCO2 modification
Trial Locations
- Locations (1)
Sainte Justine's Hospital
🇨🇦Montréal, Quebec, Canada