Impact of CO2 on Cerebral Blood Flow in Infants Less Than 6 Months During General Anaesthesia
Trial Snapshot
- Phase
- Not Applicable
- Status
- Completed
- Sponsor
- Enrollment
- 60
- Locations
- 2
- Primary Endpoint
- NIRS variation
Study Overview
Brief Summary
The study aims at assessing cerebral blood flow variations following expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia.
Detailed Description
The study aims at assessing cerebral blood flow (measured with Near-Infrared Reflectance Spectroscopy - NIRS - and transcranial Doppler - DTC) variations following end-tidal expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia performed according to standards of care.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Basic Science
- Masking
- None
Masking Description
Patient is under general anesthesia
Eligibility Criteria
- Ages
- — to 6 Months (Child)
- Sex
- All
- Accepts Healthy Volunteers
- Yes
Inclusion Criteria
- •Age < or = 6 months
- •ASA class < or = 3
- •General anesthesia required for surgery
Exclusion Criteria
- •No parental consent
- •Emergency surgery
- •Preexisting neurological condition
- •Hemodynamic instability
- •Preexisting hypoxemia and/or hypercapnia
- •Laparoscopy or thoracoscopy, if expected EtCO2 level achieving would require unsafe ventilation parameters
Arms & Interventions
Main Arm
In each patient, under ongoing standard general anesthesia in a stable state, EtCO2 is manually modified to reach predefined values, and after waiting until cerebral blood flow has reached steady state, NIRS and DTC values are noted.
Intervention: EtCO2 modification (Procedure)
Outcomes
Primary Outcomes
NIRS variation
Time Frame: 5 to 10 minutes
Near-Infrared Spectroscopy value variation after EtCO2 modification
Secondary Outcomes
- DTC variation(5 to 10 minutes)
Investigators
Bruno Greff
Principal Investigator
St. Justine's Hospital