Impact of CO2 on Cerebral Blood Flow in Infants Less Than 6 Months During General Anaesthesia

Not Applicable

Completed

• Conditions: Anesthesia, General; Infant

• Registration Number: NCT03567031
• Lead Sponsor: St. Justine's Hospital

Brief Summary

The study aims at assessing cerebral blood flow variations following expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia.

Detailed Description

The study aims at assessing cerebral blood flow (measured with Near-Infrared Reflectance Spectroscopy - NIRS - and transcranial Doppler - DTC) variations following end-tidal expired CO2 variations in anaesthetized infants less than 6 months, during a routine general anesthesia performed according to standards of care.

Study Timeline

• Study Start: 2017-11-27
• Study First Submitted: 2018-05-23
• Study First Submitted QC: 2018-06-21
• Study First Posted: 2018-06-25
• Primary Completion: 2019-03-03
• Study Completion: 2019-03-03
• Status Verified: 2019-10
• Last Update Submitted: 2019-10-02
• Last Update Posted: 2019-10-03

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 60

Inclusion Criteria

• Age < or = 6 months
• ASA class < or = 3
• General anesthesia required for surgery

Exclusion Criteria

• No parental consent
• Emergency surgery
• Preexisting neurological condition
• Hemodynamic instability
• Preexisting hypoxemia and/or hypercapnia
• Laparoscopy or thoracoscopy, if expected EtCO2 level achieving would require unsafe ventilation parameters

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SINGLE_GROUP

Primary Outcome Measures

Name	Time	Method
NIRS variation	5 to 10 minutes	Near-Infrared Spectroscopy value variation after EtCO2 modification

Secondary Outcome Measures

Name	Time	Method
DTC variation	5 to 10 minutes	Transcranial Doppler values variation after EtCO2 modification

Trial Locations

Locations (1)

Sainte Justine's Hospital; 🇨🇦 Montréal, Quebec, Canada