Red Light Ptosis Proof-of-Concept

Not Applicable

Recruiting

• Conditions: Mitochondrial Diseases; Blepharoptosis
• Interventions: Device: Near-infrared light

• Registration Number: NCT06292182
• Lead Sponsor: University College, London

Brief Summary

This study tests a new treatment to help with droopy eyelids (ptosis) and eye movement problems (squint) in children and young people with genetically confirmed mitochondrial conditions - using red-light.

We use a torch to shine a red light through the closed eyelid for 3 minutes a day. The study will run for 18 months.

We believe that this treatment could help strengthen the muscle in the eyelid to make it easier to open the eyes, and could also help some children with squint.

Detailed Description

Not available

Study Timeline

• Status Verified: 2024-02
• Study Start: 2024-02-08
• Study First Submitted: 2024-02-27
• Study First Submitted QC: 2024-02-27
• Last Update Submitted: 2024-02-27
• Study First Posted: 2024-03-05
• Last Update Posted: 2024-03-05
• Primary Completion: 2025-11-30
• Study Completion: 2025-11-30

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 10

Inclusion Criteria

Not provided

Exclusion Criteria

Not provided

Study & Design

• Study Type: INTERVENTIONAL
• Study Design: SEQUENTIAL

Arm && Interventions

Group	Intervention	Description
Treatment start at baseline	Near-infrared light	-
Delayed treatment start at 3 months from baseline	Near-infrared light	-

Primary Outcome Measures

Name	Time	Method
Palpebral fissure width	3 months from baseline

Trial Locations

Locations (1)

Moorfields Eye Hospital NHS Foundation Trust; 🇬🇧 London, United Kingdom