Dose-dependent Effects of Oxytocin on the Amygdala and Reward System Vary Between Women and Men
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 发起方
- 入组人数
- 92
- 试验地点
- 1
- 主要终点
- Neural substrates of emotion processing, measured via blood-oxygen-level dependent signal in the amygdala
研究概览
简要总结
The purpose of this study is to determine whether effects of intranasal oxytocin on amygdala and reward system responses vary as a function of treatment dose in women in comparison to men.
详细描述
The objective of the present study is to determine whether intranasal oxytocin (IN-OXT) effects on blood oxygenation level-dependent functional magnetic resonance imaging (BOLD fMRI) in the amygdala and striatal regions (putamen, nucleus accumbens, caudate, pallidum) vary as a function of dose. In particular, the investigators plan to compare effects of three different IN-OXT doses (6, 12, and 24 international units, IU) on established neural and behavioural correlates of emotion processing in women. Results will be discussed in comparison to a previous study of OXT kinetics in men.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Crossover
- 主要目的
- Basic Science
- 盲法
- Triple (Participant, Investigator, Outcomes Assessor)
入排标准
- 年龄范围
- 18 Years 至 40 Years（Adult）
- 性别
- Female
- 接受健康志愿者
- 是
入选标准
- •Healthy female volunteers
- •Right-handed
- •Non-smoker
排除标准
- •Current psychiatric or physical illness
- •Hormonal contraception
- •Psychoactive medication
- •MRI contraindication (e.g. metal in body, claustrophobia)
- •Pregnancy
研究组 & 干预措施
Oxytocin & Placebo, 6 IU
Intranasal administration, 6 IU oxytocin nasal spray or placebo. Imaging starting 45 min after nasal spray administration.
干预措施: Oxytocin nasal spray (Drug)
Oxytocin & Placebo, 6 IU
Intranasal administration, 6 IU oxytocin nasal spray or placebo. Imaging starting 45 min after nasal spray administration.
干预措施: Placebo (Drug)
Oxytocin & Placebo, 12 IU
Intranasal administration,12 IU oxytocin nasal spray or placebo. Imaging starting 45 min after nasal spray administration.
干预措施: Oxytocin nasal spray (Drug)
Oxytocin & Placebo, 12 IU
Intranasal administration,12 IU oxytocin nasal spray or placebo. Imaging starting 45 min after nasal spray administration.
干预措施: Placebo (Drug)
Oxytocin & Placebo, 24 IU
Intranasal administration, 24 IU oxytocin nasal spray or placebo. Imaging starting 45 min after nasal spray administration.
干预措施: Oxytocin nasal spray (Drug)
Oxytocin & Placebo, 24 IU
Intranasal administration, 24 IU oxytocin nasal spray or placebo. Imaging starting 45 min after nasal spray administration.
干预措施: Placebo (Drug)
结局指标
主要结局
Neural substrates of emotion processing, measured via blood-oxygen-level dependent signal in the amygdala
时间窗: 45 min after nasal spray administration
Functional magnetic resonance imaging (fMRI) will be performed to measure blood-oxygen-level dependent signal in response to emotional face stimuli. The investigators specifically plan to investigate amygdala responses to emotional faces, because previous studies found sex-specific effects of oxytocin on amygdala activation.
Neural substrates of emotion processing, measured via blood-oxygen-level dependent signal in striatal regions (putamen, nucleus accumbens, caudate, pallidum)
时间窗: 45 min after nasal spray administration
Functional magnetic resonance imaging (fMRI) will be performed to measure blood-oxygen-level dependent signal in response to emotional face stimuli. The investigators specifically plan to investigate striatal responses to emotional faces to explore sex-specific effects of OXT on reward-related brain activation.
次要结局
未报告次要终点
研究者
Rene Hurlemann
Chair of the Medical Psychology Division and Deputy Chair of the Department of Psychiatry
University Hospital, Bonn