Midazolam and mORPHine to alleviate symptoms at the End of life in patients on acUte geriatric wardS (MORPHEUS study)
试验速览
- 阶段
- 4 期
- 状态
- 招募中
- 发起方
- UZ Leuven
- 入组人数
- 300
- 试验地点
- 2
- 主要终点
- Morphine and midazolam doses, time of administration and route of administration
研究概览
简要总结
- To characterize the relationship between morphine dosing and the time to symptom control (discomfort/pain and dyspnea) in geriatric patients during their last days of life.
- To characterize the relationship between midazolam dosing and the time to symptom control (discomfort/pain, dyspnea and agitation) in geriatric patients during their last days of life.
- To characterize the relationship between morphine dosage and the occurrence of adverse drug reactions in geriatric patients during their last days of life.
- To characterize the relationship between midazolam dosage and the occurrence of adverse drug reactions in geriatric patients during their last days of life.
入排标准
- 年龄范围
- 65 years 至 65+ years（65+ Years）
- 接受健康志愿者
- 是
入选标准
- •Hospitalization on the acute geriatric ward
- •Patient expected to die in the following hours or days
排除标准
- •Expected discharge from the hospital before death
结局指标
主要结局
Morphine and midazolam doses, time of administration and route of administration
Morphine and midazolam doses, time of administration and route of administration
Symptom control: discomfort scale, agitation/sedation scale and dyspnea scale
Symptom control: discomfort scale, agitation/sedation scale and dyspnea scale
Adverse reactions: : nausea, vomiting, hallucinations, constipation, myoclonus, pruritus, hiccups, respiratory rate and other adverse reactions occurring that are related to the Morphine and Midazolam injection according to the nurse or doctor.
Adverse reactions: : nausea, vomiting, hallucinations, constipation, myoclonus, pruritus, hiccups, respiratory rate and other adverse reactions occurring that are related to the Morphine and Midazolam injection according to the nurse or doctor.
次要结局
- Morphine, morphine-3-glucuronide and morphine-6-glucuronide plasma concentrations
- Midazolam and alpha-hydroxy-midazolam glucuronide plasma concentrations
- Blood creatinine, urea, albumin, bilirubin, GGT, ALT, sodium, CRP and urinary creatinine concentrations
研究者
Tim Biesbrouck
Scientific
UZ Leuven