Acute Kidney Injury and Recovery Mode in Pediatric Liver Transplantation
- Conditions
- Postoperative Acute Kidney InjuryPediatric Liver Transplantation
- Registration Number
- NCT06598228
- Lead Sponsor
- Wei Gao
- Brief Summary
Acute kidney injury (AKI) is a common complication after pediatric liver transplantation (PLT), and renal impairment after LT has proven to be related with increased graft failure and mortality. The recovery mode of kidney injury after PLT has not been systematically studied. Therefore, in this study we aimed to systematically evaluate prognosis of AKI after PLT, combine the recovery mode of AKI with related risk factors, and establish a relationship between AKI and CKD.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 700
Patients who received a liver transplant for the first time and were younger than 18 years of age at the time of transplant.
Patients with incomplete clinical data. Patients with less than 5 years of follow-up. Patients who have combined multiple solid organ transplants. Patients with preoperative renal impairment (eGFR < 60ml/min/1.73 m2 or prior renal replacement therapy).
Study & Design
- Study Type
- OBSERVATIONAL
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Graft survival Based on the most recent follow-up before December 31, 2023. The investigators collected clinical data of patients from 2014 to 2018, and followed enrolled participants until at least 5 years after surgery Loss of graft is defined as patient death or secondary transplantation
- Secondary Outcome Measures
Name Time Method
Trial Locations
- Locations (1)
Tianjin First Central Hospital
🇨🇳Tianjin, China