Effect of injection of methotrexate or triamcinolone in the nail for treatment of nail psoriasis

Phase 3

Recruiting

• Conditions: ail psoriasis.; Other psoriasis; L40.8

• Registration Number: IRCT20140212016557N7
• Lead Sponsor: Shiraz University of Medical Sciences

Brief Summary

Not available

Detailed Description

Not available

Study Timeline

• Results First Posted: 1900-01-01
• Last Update Posted: 26 May 2021

Recruitment & Eligibility

• Status: Recruiting
• Sex: All
• Target Recruitment: 78

Inclusion Criteria

Patients between 16 and 70 years of age
Clinically- or pathologically confirmed nail psoriasis that have involvement of one or more fingernails with psoriasis

Exclusion Criteria

Patients with involvement of 5 or more nails
Patients who received systemic or topical medication (for nail) in the last 3 months
Patients with skin involvement of more than 20% that need systemic treatment
Patients with nail fungal infection
History of hypersensitivity reactions to lidocaine, triamcinolone, or methotrexate
Diabetic patients
Pregnancy
Lactation
Immunocompromised patients
Patients with active peptic ulcer, gastritis, ascitis, and pleural effusion
Concomitant use of hepatotoxic drugs, or drugs that interfere with methotrexate metabolism
Concomitant radiotherapy
Active or severe infection
Decreased pulmonary function
Renal failure

Study & Design

• Study Type: interventional
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Severity of nail involvement with psoriasis. Timepoint: At the beginning of treatment and weeks 3 ,6, 9, 12, 15, and 23. Method of measurement: modified Nail Psoriasis Severity Index (mNAPSI), measured by inspection and scoring of the severity of psoriasis features in nail matrix and bed.

Secondary Outcome Measures

Name	Time	Method
Quality of life index. Timepoint: At the beginning and end of treatment. Method of measurement: Dermatology quality of life index questionnaire.;Pain severity during injection. Timepoint: At the beginning of treatment and weeks 3 ,6, 9, 12, 15, and 23. Method of measurement: illustrated numerical rating scale.