Continuous Norepinephrine Administration and Blood Pressure Stability During Anesthetic Induction - A Randomized Controlled Trial
Overview
- Phase
- Not Applicable
- Intervention
- Not specified
- Conditions
- Blood Pressure
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
- Enrollment
- 72
- Locations
- 1
- Primary Endpoint
- Blood pressure stability
- Status
- Completed
- Last Updated
- last year
Overview
Brief Summary
This is a randomized trial investigating whether continuous norepinephrine administration via an infusion pump - compared to manual bolus administration - increases blood pressure stability within the first 15 minutes of anesthetic induction in non-cardiac surgery patients.
The secondary endpoints area under a MAP of 65, 60, 50, and 40 mmHg [mmHg × min], cumulative duration of a MAP <65, <60, <50, and <40 mmHg [min], area above a MAP of 100, 110, 120, and 140 mmHg [mmHg min], cumulative duration of a MAP >100, >110, >120, and >140 mmHg [min] and cumulative dose of norepinephrine indexed to body weight [μg/kg] within the first 15 minutes of anesthetic induction will be assessed.
Detailed Description
not provided
Investigators
Eligibility Criteria
Inclusion Criteria
- •age ≥ 45 years
- •American Society of Anesthesiologists physical status II-IV
- •scheduled for elective major non-cardiac surgery under general anesthesia
- •continuous intraarterial blood pressure monitoring using a radial arterial catheter for clinical indications not related to the trial
- •sinus rhythm
Exclusion Criteria
- •Clinical indication to use a continuous norepinephrine infusion via an infusion pump during anesthetic induction
- •Need for femoral artery catheterization
- •History of intracranial bleedings or aneurysms
- •Patients who are incapable of giving consent
- •Pregnancy
Outcomes
Primary Outcomes
Blood pressure stability
Time Frame: Measurement period of 15 minutes starting at the beginning of the anesthetic induction
Generalized average real variability (gARV) of mean arterial pressure (MAP) within the first 15 minutes of anesthetic induction \[mmHg/min\]; the gARV is the sum of absolute values of the differences between neighboring measurements for all measurements divided by the total measurement duration in \[mmHg/min\].
Secondary Outcomes
- Area under MAP(Measurement period of 15 minutes starting at the beginning of the anesthetic induction)
- Cumulative duration of a MAP below(Measurement period of 15 minutes starting at the beginning of the anesthetic induction)
- Cumulative dose of norepinephrine(Measurement period of 15 minutes starting at the beginning of the anesthetic induction)
- Area above MAP(Measurement period of 15 minutes starting at the beginning of the anesthetic induction)
- Cumulative duration of a MAP above(Measurement period of 15 minutes starting at the beginning of the anesthetic induction)