Detailed Evaluation of the Neurophysiology of Surround Inhibition in the Human Motor Cortex
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 53
- 试验地点
- 1
- 主要终点
- Substudy 1 EEG analysis: we will measure the latency and amplitude of the different components of the TMS-evoked potentials
研究概览
简要总结
Background:
Movement disorders have many different causes and symptoms. Researchers still do not fully understand which parts of the brain are involved in fine movement. They want to learn about which brain regions could be abnormal in people with movement disorders.
Objective:
To better understand how the brain controls movement.
Eligibility:
Healthy, right-handed adults age 18-70 years old.
Design:
Participants will be screened with a physical exam and questions about their handedness. They may have a urine test.
Participants will have 1 or 2 clinic visits. The first visit will last about 1.5 hours. The second will last about 3 hours.
Participants will have structural magnetic resonance imaging (MRI). A strong magnetic field and radio waves take pictures of the brain. Participants will lie on a table that slides in and out of a metal cylinder.
Participants may have transcranial magnetic stimulation. A wire coil is held on the scalp. A brief electrical current is passed through the coil and creates a magnetic pulse that stimulates the brain. Participants will wear a pair of glasses or a headband with small sensors so researchers can track head position.
Participants will perform a simple index finger movement task.
Participants may have surface electromyography from at least two hand muscles. Small metal disk or adhesive pad electrodes will be taped to the skin. Participants will be seated in a comfortable chair with their hands placed on a pillow.
Participants may have an electroencephalography. A cap with small disc electrodes will be placed on the scalp.
详细描述
Objectives:
The purpose of this protocol is to improve understanding of the neurophysiological mechanisms that underlie the phenomenon of surround inhibition in the human motor cortex. It is known that patients with focal hand dystonia have abnormal motor surround inhibition. However, the physiology of this phenomenon still remains unclear. The 3 sub-studies proposed under this protocol will integrate several neurophysiological techniques to explore different aspects of motor surround inhibition. The objectives of sub-study 1 are (a) to identify the EEG correlate of motor SI (b) to determine the relationship between short interval intracortical inhibition (SICI) and SI, both of which are compromised in patients with FHD and (c) to determine if there is an oscillatory frequency band that is relevant for SI. The results from this sub-study will shed light on the inhibitory mechanisms that are critical for motor SI. Sub-study 2 is aimed at determining the influence of parietal conditioning on motor surround inhibition. If conditioning the parietal cortex enhances SI, we can conclude that the parieto-motor inhibitory network may be involved in motor SI and that this network could be affected in focal hand dystonia. Sub-study 3 will explore SI during different motor tasks.
Study population:
We intend to study up to 95 healthy volunteers in total. Up to 30 participants will be recruited for sub-study 1, 35 for sub-study 2, and 30 for sub-study 3.
Design:
研究设计
- 研究类型
- Observational
- 观察模型
- Cohort
- 时间视角
- Prospective
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- 未提供
排除标准
- 未提供
结局指标
主要结局
Substudy 1 EEG analysis: we will measure the latency and amplitude of the different components of the TMS-evoked potentials
时间窗: throughout
EEG: For the EEG analysis, we will measure the latency and amplitude of the different components of the TMS-evoked potentials. Time-frequency analysis on the collected EEG data will provide valuable information on which frequency bands are involved in the phenomenon of motor SI. The coherence calculated between relevant brain regions will also reveal information on the changes in cortical connectivity during the phenomenon of SI.
Substudy 1 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal
时间窗: throughout
TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single/paired pulse TMS will give information about the corticospinal excitability. The latency of the MEP will revealmore information on which neuronal networks were activated.
Substudy 3 EMG: The EMG amplitude during certain tasks will reveal information about the level of muscle activation.
时间窗: throughout
EMG: The EMG amplitude during certain tasks will reveal information about the level of muscle activation.
Substudy 2 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single /paired pulse TMS at rest or movement onset will give information about the corticospinal excitability.
时间窗: throughout
TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single/paired pulse TMS at rest or movement onset will give information about the corticospinal excitability.
Substudy 3 TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single pulse TMS at rest or during a motor task will give information about the corticospinal excitability.
时间窗: throughout
TMS: The amplitude of the motor evoked potential (MEP) in the EMG signal elicited by single pulse TMS at rest or during a motor task will give information about the corticospinal excitability.
次要结局
未报告次要终点