Improving Cognitive Functions with Frontal-vagal rTMS in Normal Aging and Cognitively Impaired adults
- Conditions
- Healthy participants
- Registration Number
- DRKS00033052
- Lead Sponsor
- niversitätsmedizin Göttingen
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Pending
- Sex
- All
- Target Recruitment
- 80
Age between 55 and 85.
1. Severe Cardiovascular diseases such as Heart Failure (EF < 45%), any Arrythmias (such as Atrial Fibrillation, Sick sinus syndrome or Bradycardias), Heart Valves Insufficiency or Stenosis;
2. History of Myocardial Infarction and/or Cardiac Arrest, CPR or Cardiovascular Surgery;
3. Heart Pacemaker or Defibrillator, or other Heart Devices;
4. Anticoagulation therapy related to cardiovascular disease;
5. Metal implants in the head area (e.g. clips after surgery of an intracerebral aneurysm, implantation of an artificial cochlea);
6. Evidence of a chronic disease or residuals (remnants) of a neurological disease (disease of the nervous system) in history; History of intracerebral ischemia (insufficient blood flow to the brain/stroke); Evidence of a history of epileptic seizures or stroke; multiple sclerosis;
6. Presence of a serious internal or neurological disease (e.g. untreated tumors, cancer, Parkinson's disease, multiple sclerosis);
7. Psychiatric diseases (schizophrenia, major depression);
8. Head trauma with a history of loss of consciousness;
9. Glaucoma, retinitis pigmentosa, macular degeneration in an advanced stadium;
10. Alcohol or drug addiction;
11. Operations within the last three months;
12. Participation in another clinical trial within the last 6 weeks.
Study & Design
- Study Type
- interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method Cognitive performance in cognitively impaired and normal aging subjects is improved on cognitive tasks after frontal-vagal rTMS intervention. Furthermore, their heart rate variability will increase by collecting EEG-ECG data after the intervention.
- Secondary Outcome Measures
Name Time Method 1. Neurocardiac-guided TMS (NCG-TMS) can optimize the stimulation site in cognitively impaired and normal aging subjects.<br>2. The combination of internal regulation (resonance frequency breathing) and external regulation (brain stimulation) is more effective in cognitive improvement than single external regulation.