Effect van koolstof nanopartikels op ontsteking en stolling in de luchtwegen.
Completed
- Conditions
- carbon nanoparticles - air pollution - lung inflammation - coagulationkoolstof nanopartikels - luchtvervuiling - luchtwegontsteking - stolling
- Registration Number
- NL-OMON29149
- Lead Sponsor
- Academic Medical Center (AMC) Amsterdam. Department of Pulmonology
- Brief Summary
/A
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 24
Inclusion Criteria
1. Healthy, male subjects between 18 and 45 years of age;
2. No clinically significant findings during physical examination and haematological and biochemical screening;
Exclusion Criteria
1. History of pulmonary or any other relevant disease;
2. History of enhanced bleeding tendency;
Study & Design
- Study Type
- Interventional
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method 1. Total leukocyte count and differentials in bronchoalveolar lavage fluid;<br /><br>2. Activation of coagulation and fibrinolysis in bronchoalveolar lavage fluid.
- Secondary Outcome Measures
Name Time Method 1. Amino acid pattern in exhaled breath condensate;<br /><br>2. Metabolomic fingerprint as obtained by Liquid chromatography-mass spectrometry (LC-MS);<br /><br>3. Safety outcome parameters (Physical complaints of the volunteer, Blood pressure, Heart rate, Temperature, Lungfunction, Oxygen saturation, (Serious) Adverse Events.