NCT01777178已完成1 期
Intradialytic Acid-base Changes and Organic Anion Production With Standard Versus Low Bicarbonate Hemodialysis
适应症
试验速览
- 阶段
- 1 期
- 状态
- 已完成
- 入组人数
- 10
- 试验地点
- 2
- 主要终点
- Post-dialysis bicarbonate
研究概览
简要总结
This study will compare acid-base changes during hemodialysis treatments with a standard dialysis bath versus a lower bicarbonate dialysis bath, and aims to define the factors that limit equilibration of the bicarbonate concentration in a patient's blood with that in the dialysate.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Treatment
- 盲法
- None
入排标准
- 年龄范围
- 19 Years 至 —（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Receiving chronic thrice-weekly conventional hemodialysis for at least 3 months
- •Age > 18 years
排除标准
- •Use of oral alkali within the previous month
- •Hospitalization within the previous month
- •Inability to provide written informed consent
- •Pregnancy
结局指标
主要结局
Post-dialysis bicarbonate
时间窗: 1-2 weeks
Post-dialysis pH
时间窗: 1-2 weeks
Change in beta-hydroxybutyrate clearance
时间窗: 1-2 weeks
Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations
Change in lactate clearance
时间窗: 1-2 weeks
Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations
次要结局
未报告次要终点
研究者
Matthew Abramowitz
Assistant Professor
Albert Einstein College of Medicine
研究点 (2)
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