Intradialytic Acid-base Changes and Organic Anion Production With Standard Versus Low Bicarbonate Hemodialysis
Trial Snapshot
- Phase
- Phase 1
- Status
- Completed
- Enrollment
- 10
- Locations
- 1
- Primary Endpoint
- Post-dialysis bicarbonate
Study Overview
Brief Summary
This study will compare acid-base changes during hemodialysis treatments with a standard dialysis bath versus a lower bicarbonate dialysis bath, and aims to define the factors that limit equilibration of the bicarbonate concentration in a patient's blood with that in the dialysate.
Study Design
- Study Type
- Interventional
- Allocation
- Na
- Intervention Model
- Single Group
- Primary Purpose
- Treatment
- Masking
- None
Eligibility Criteria
- Ages
- 19 Years to — (Adult, Older Adult)
- Sex
- All
- Accepts Healthy Volunteers
- No
Inclusion Criteria
- •Receiving chronic thrice-weekly conventional hemodialysis for at least 3 months
- •Age > 18 years
Exclusion Criteria
- •Use of oral alkali within the previous month
- •Hospitalization within the previous month
- •Inability to provide written informed consent
- •Pregnancy
Arms & Interventions
Low bicarbonate dialysis
Intervention: Low bicarbonate dialysis (Other)
Outcomes
Primary Outcomes
Post-dialysis bicarbonate
Time Frame: 1-2 weeks
Post-dialysis pH
Time Frame: 1-2 weeks
Change in beta-hydroxybutyrate clearance
Time Frame: 1-2 weeks
Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations
Change in lactate clearance
Time Frame: 1-2 weeks
Comparison between 2 hemodialysis treatments with different bicarbonate dialysis concentrations
Secondary Outcomes
No secondary outcomes reported
Investigators
Matthew Abramowitz
Assistant Professor
Albert Einstein College of Medicine