Maximizing the Dietary Pattern of Older Adults: the Effects of Protein Intake on Protein Kinetics
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 44
- 试验地点
- 1
- 主要终点
- Whole Body Protein Turnover
研究概览
简要总结
A randomized study to demonstrate how animal-based protein-rich food sources can be used by older adults to increase protein intake within pre-existing dietary patterns.
详细描述
Current dietary patterns of older Americans will be augmented by readily available quality protein sources. Investigators will observe the effects of recommended and common protein intakes on the maintenance of whole-body protein balance and potential for muscle protein anabolism.
3 groups of 10 older subjects will be studied during daily protein intakes. Study duration per subject will be about 2 weeks.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Prevention
- 盲法
- Single (Outcomes Assessor)
入排标准
- 年龄范围
- 50 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 是
入选标准
- •BMI ≤ 35 kg/m2
- •Capable of providing informed consent
- •COVID-19 negative and/or asymptomatic
排除标准
- •Subject who does not/will not eat animal protein sources.
- •Body mass index >
- •History of chemotherapy or radiation therapy for cancer in the 6 months prior to enrollment.
- •Use of insulin to control blood sugar level.
- •Currently receiving androgen (e.g., testosterone) or anabolic (e.g., GH, IGF-I) therapy.
- •Currently using prescription blood thinning medications.
- •Unable or unwilling to suspend aspirin use for 7 days prior to Visit
- •Unwilling to avoid using protein or amino-acid supplements during participation.
研究组 & 干预措施
Recommended dietary allowance (RDA) for protein
(RDA; 0.8g/kg/day) Protein intakes will be structured within two meals per day. A 2-day dietary lead-in will precede each dietary intervention. Study duration per subject will last about two weeks.
干预措施: Recommended Dietary Allowance of Protein (Other)
Habitual protein intake consistent with population level norms
(NHANES; 1.0g/kg/day) Protein intakes will be structured within two meals per day. A 2-day dietary lead-in will precede each dietary intervention. Study duration per subject will last about two weeks.
干预措施: Habitual protein intake (Other)
Optimal protein intake (OPI)
(OPI; 1.5g/kg/day) Protein intakes will be structured within two meals per day. A 2-day dietary lead-in will precede each dietary intervention. Study duration per subject will last about two weeks.
干预措施: Optimal Protein Intake (Other)
结局指标
主要结局
Whole Body Protein Turnover
时间窗: 24 hour
Isotope Tracer
次要结局
未报告次要终点