Vascular Impact of Omega-3 in Metabolic Syndrome
Not Applicable
Completed
- Conditions
- Metabolic SyndromeEssential Hypertension
- Registration Number
- NCT01566188
- Lead Sponsor
- University Hospital, Rouen
- Brief Summary
The overall aims of the present project are to investigate the impact of a nutritional approach based on omega-3 from vegetal origin on vascular function in hypertension associated with metabolic syndrome.
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- COMPLETED
- Sex
- All
- Target Recruitment
- 95
Inclusion Criteria
- Female and male patients with treated essential hypertension (blood pressure values<140/90 mmHg under antihypertensive treatment).
- Presence of at least two of the following criteria of the metabolic syndrome: abdominal girth >102 cm in men or >88 cm in women, HDL-C<0.4 g/L in men or <0.5 g/L in women, fasting triglyceride >1.5 g/L (or specific treatment for these lipid abnormalities), fasting glucose >1.10 g/L.
Exclusion Criteria
- Secondary hypertension, myocardial infarction, coronary artery disease, cerebrovascular disease, stroke or transient ischemia, cardiac failure, diabetes (or fasting glucose>1.26 g/L) or renal failure (MDRD < 50 ml/min)
- Severe hypercholesterolemia (total cholesterol > 2.5 g/l), alcohol or drug abuse, toxicomania, or clinically significant abnormalities in other current biological parameters.
Study & Design
- Study Type
- INTERVENTIONAL
- Study Design
- PARALLEL
- Primary Outcome Measures
Name Time Method Brachial artery flow-mediated dilatation 6 months after omega-3 supplementation
- Secondary Outcome Measures
Name Time Method Aortic stiffness 6 months after omega-3 supplementation carotid-to-femoral pulse wave velocity
Trial Locations
- Locations (4)
Mahes Hospital
🇫🇷Fleury-Mérogis, France
George Pompidou European Hospital
🇫🇷Paris, France
Rouen University Hospital
🇫🇷Rouen, France
Rangueil University Hospital
🇫🇷Toulouse, France
Mahes Hospital🇫🇷Fleury-Mérogis, France