Sensory weigthing and reweigthting of proprioceptive information during balance control in elderly
- Conditions
- Balance disordersBalance problems100192431002830210028037
- Registration Number
- NL-OMON35317
- Lead Sponsor
- eids Universitair Medisch Centrum
- Brief Summary
Not available
- Detailed Description
Not available
Recruitment & Eligibility
- Status
- Completed
- Sex
- Not specified
- Target Recruitment
- 60
- aged between 20 and 30 years.
- aged 75 years or older, free living, ADL independent.
- aged 75 years or older with a known polyneuropathy diagnosed in the past five years.
- aged 75 years or older with a known visual impairment due to cataract
- aged 75 years or older and not possible to stand 10 seconds in semi-tandem stance
- Patients unable to give a personal consent;
- Walking distance 250m or less;
- MMSE 23 or lower;
- GDS 5 or higher;
- Institutionalized;
- Comorbidity: neurological disorders (stroke, M. Parkinson, dementia, muscle disease), metabolic diseases (diabetes mellitus), arthritis: rheumatoid arthritis, severe (pain and functional limitation) osteoarthritis (hip and knee), cancer: diagnosis and treatment of cancer within the last year, polymyalgia rheumatic, heart failure (NYHA 3-4), COPD (Gold 3-4), chronic pain syndrome (fibromyalgia, complex regional pain syndrome etc);
- Medication: immunosuppressive drugs (e.g. prednisone, methotrexat, biologicals (TNF-alpha antagonists etc)), insulin
- Hip or knee replacement;
- Amputation;
- Immobilization for 1 week or longer during the last 3 months;
- Severe visual (visus < 0.6) and/or hearing impairment.
Study & Design
- Study Type
- Observational non invasive
- Study Design
- Not specified
- Primary Outcome Measures
Name Time Method <p>The primary study parameters are the sensory weights of the proprioceptive<br /><br>information. The change of the sensory weights over the conditions with<br /><br>increasing perturbation amplitude of the proprioceptive information is a<br /><br>measure of sensory reweighting. The sensory reweighting can be represented by<br /><br>the slope of the relation proprioceptive weight and perturbation amplitude<br /><br>increase. Both, the proprioceptive reweighting of the left and right leg are<br /><br>calculated. </p><br>
- Secondary Outcome Measures
Name Time Method <p>The outcomes of the tests performed in the diagnostic street of the Bronovo<br /><br>geriatrics Treatment Advice Center are secondary outcome measures of the<br /><br>present study:<br /><br>* Length, arm span, waist size, hip size and stand width<br /><br>* Muscle mass by Bio Impedance Analysis (BIA)<br /><br>* Hand grip strength by a hand held dynamometer<br /><br>* Isometric quadriceps strength<br /><br>* Visus, propriocepsis and vestibular function<br /><br>* Short Physical Performance Battery<br /><br>* Balance tests with closed eyes<br /><br>* Time up and go with and without a cognitive tasks<br /><br>* Walking speed during 10 meter walking test with and without cognitive task<br /><br>* Blood pressure after 5 minutes rest in supine position and after 1 minute and<br /><br>3 minutes during stance<br /><br>* Cardiac output measured using a finometer</p><br>