Chorioamnionitis and Proinflammatory S100A12

Completed

• Conditions: Chorioamnionitis Affecting Fetus or Newborn

• Registration Number: NCT02996279
• Lead Sponsor: Catholic University of the Sacred Heart

Brief Summary

Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS) and increased levels of proinflammatory molecules.

Detailed Description

Histologic chorioamnionitis (HCA) may lead to the fetal inflammatory response syndrome (FIRS). The aim of this pilot study was to evaluate S100A12, a marker of innate immune activation, in mothers with or without HCA and in their infants.

Concentrations of S100A12, Interleukin 6 (IL-6) and C-reactive protein (CRP) were evaluated in maternal, cord, and neonatal blood of very preterm infants. Histologic examinations of placentae and umbilical cords were performed.

Study Timeline

• Study Start: 2012-02
• Primary Completion: 2013-02
• Study Completion: 2013-03
• Study First Submitted: 2016-11-25
• Status Verified: 2016-12
• Study First Submitted QC: 2016-12-14
• Last Update Submitted: 2016-12-14
• Study First Posted: 2016-12-19
• Last Update Posted: 2016-12-19

Recruitment & Eligibility

• Status: COMPLETED
• Sex: All
• Target Recruitment: 69

Inclusion Criteria

Preterm Birth

Exclusion Criteria

Congenital Abnormalities

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
S100A12 in Presence of Maternal Chorioamnionitis	1 Year	Levels of S100A12 in Maternal, Cord and Neonatal Blood in the Presence or Absence of HCA