NCT04152005已完成不适用
Analysis of Endothelin Concentrations in a Population With Cardiovascular Disease and Periodontitis
适应症
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 165
- 试验地点
- 1
- 主要终点
- Evaluation of ET-1 levels
研究概览
简要总结
Recently, a key role played in the ethiology of periodontitis has been highlighted by a Endothelin (ET-1). ET1 possess the ability to express surface antigens of endothelial and hematopoietic stem cells and to assist in maintaining vascular integrity and the repair mechanism of the endothelium. ET originate from bone marrow
详细描述
The aim of the present study was to investigate the association between ET-1 in patients with periodontitis. Furthermore, the objective was to determine if the periodontal status influenced ET-1 levels.
研究设计
- 研究类型
- Observational
- 观察模型
- Case Control
- 时间视角
- Cross Sectional
入排标准
- 年龄范围
- 21 Years 至 71 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Presence of at least 16 teeth
- •CP with a minimum of 40% of sites with a clinical attachment level (CAL)
- •≥2mm and probing depth (PD) ≥4mm;
- •Presence of at least ≥2 mm of crestal alveolar bone loss verified on digital periapical radiographs
- •Presence of ≥40% sites with bleeding on probing (BOP)
排除标准
- •Intake of contraceptives
- •Intake of immunosuppressive or anti-inflammatory drugs throughout the last three months prior to the study
- •Status of pregnancy or lactation
- •Previous history of excessive drinking
- •Allergy to local anaesthetic
- •Intake of drugs that may potentially determine gingival hyperplasia such as Hydantoin, Nifedipine, Cyclosporin A or similar drugs.
结局指标
主要结局
Evaluation of ET-1 levels
时间窗: 1 year
Correlation of ET-1 levels with periodontal and cardiovascular disease
次要结局
未报告次要终点
研究者
Gaetano Isola, DDS, PhD
Assistant Professor
University of Messina
研究点 (1)
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