Vitiligo Severity, Quality of Life, Work Productivity and Activity Impairment

Not yet recruiting

• Conditions: Vitiligo

• Registration Number: NCT06877000
• Lead Sponsor: Assiut University

Brief Summary

translate and validate the vitiligo specific quality of life (VITIQOL) questionnaire to Arabic language.

evaluate the effect of vitiligo on patient quality of life using vitiligo specific quality of life questionnaire (VitiQoL).

measure the impact of vitiligo on work productivity using work productivity and activity impairment questionnaire (WPAI) and general self efficacy scale (GSE) .

analyze how disease severity and location influence patients quality of life and work pro

Detailed Description

Vitiligo is a common disorder of depigmentation caused by the progressive destruction of melanocytes that affect the skin, hair and mucous membranes, clinically presenting as depigmented macules and leukotrichia.

Vitiligo was historically regarded as a cosmetic disorder; however, it is an immune disease as it affects patient well-being . It affects approximately 0.5-1% of the global population. A Study reported a prevalence of 1.2% in the Egyptian population.

Vitiligo is asymptomatic disease, so its effect on quality of life is much more related to psychological problems, such as lack of self-confidence unpleasant body images unsuccessful social relationships, and lower quality of marital relations, than the exclusive physical issues. It has been shown that patients with vitiligo are at risk of higher social discrimination and stigma Lesions that are more severe, on the face, or covering a greater BSA are more often associated with poorer outcomes and activity impairment.

Recently a study conducted in Egypt in 2023 noted that more than half of studied sample had low level of self-esteem and quality of life. While more than half of studied sample had moderate negative body image. Also, half of studied sample had moderate level of social problems .

limited studies have been conducted in Upper Egypt which assess life quality of patients with vitiligo and but those Studies employed non-specific tools like Dermatology Life Quality Index (DLQI).

Lilly et al have developed a reliable tool with high internal consistency named as Vitiligo specific Quality of life questionnaire(VITIQOL) that consists of 16 questions comprising of demographic and clinical parameters of the patients.

Also the work productivity and activity impairment among vitiligo patients in Egypt have not been assessed before .

Study Timeline

• Status Verified: 2025-03
• Study First Submitted: 2025-03-06
• Study First Submitted QC: 2025-03-10
• Last Update Submitted: 2025-03-10
• Study First Posted: 2025-03-14
• Last Update Posted: 2025-03-14
• Study Start: 2025-11-01
• Primary Completion: 2027-11-01
• Study Completion: 2028-01-01

Recruitment & Eligibility

• Status: NOT_YET_RECRUITING
• Sex: All
• Target Recruitment: 400

Inclusion Criteria

• Adults > 18 years and less than 60 years old diagnosed with vitiligo by a physician Patients willing to complete the survey questionnaires Patients who can speak Arabic

Exclusion Criteria

• Patients with other major skin disease affecting QOL . Patient with chronic diseases as diabetes mellitus and hypertension Not working patients

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Arabic validated version of vitiligo specific quality of life instrument VITIQOL	Baseline	A translated version will help to measure impact of vitiligo in Arabs
Patients with severe vitiligo which will be measured by vitiligo area scoring index VASI score , will have lower quality-of-life on vitiligo specific quality of life instrument which have a score ranges from 0 to 90	Baseline	Vitiligo specific quality of life instrument have 15 questions each one has a likert scale from 0 to 6 , score ranges from 0-90 , patients with severe vitligo expect to have low score on the questionnaire
patients with more severe vitiligo have low work productivity and more activity impairment	Baseline	Work Productivity and Activity impairments questionnaire is a 6 question questionnaire consists of four consists of four metric : 1. Absenteeism (the percentage of work time missed); 2. Presentism (the percentage of impairment experienced while at work); 3. Overall work productivity loss (an estimate of combination of absenteeism and presentism); 4. Activity impairment (the percentage of impairment in daily activities) WPAI outcomes are expressed as impairment percentages, with higher numbers indicating greater impairment and less productivity .