Pompe Disease Registry Protocol

Recruiting

• Conditions: Glycogen Storage Disease Type II; Pompe Disease

• Registration Number: NCT00231400
• Lead Sponsor: Genzyme, a Sanofi Company

Brief Summary

The Pompe Registry is a global, multicenter, international, longitudinal, observational, and voluntary program for patients with Pompe disease, designed to track the disease's natural history and outcomes in patients, both treated and not. Data from the Registry are also used to fulfill various global regulatory commitments, to support product development/reimbursement, and for other research and non-research related purposes.

The objectives of the Registry are:

* To enhance understanding of the variability, progression, identification, and natural history of Pompe disease, with the ultimate goal of better guiding and assessing therapeutic intervention.

* To assist the Pompe medical community with the development of recommendations for monitoring patients, and to provide reports on patient outcomes, to optimize patient care.

* To characterize the Pompe disease population.

* To evaluate the long-term effectiveness of alglucosidase alfa.

Detailed Description

Study Design Time Perspective: Retrospective and Prospective

Study Timeline

• Study Start: 2004-09-15
• Study First Submitted: 2005-09-30
• Study First Submitted QC: 2005-09-30
• Study First Posted: 2005-10-04
• Status Verified: 2025-05
• Last Update Submitted: 2025-05-19
• Last Update Posted: 2025-05-21
• Primary Completion: 2034-01-31
• Study Completion: 2034-01-31

Recruitment & Eligibility

• Status: RECRUITING
• Sex: All
• Target Recruitment: 2000

Inclusion Criteria

All patients with a confirmed diagnosis of Pompe disease who have signed the informed consent and authorization form(s) are eligible for inclusion. Confirmed diagnosis is defined as documented GAA enzyme deficiency from blood, skin, or muscle tissue and/or documentation of 2 GAA gene mutations.

Exclusion Criteria

There are no exclusion criteria in this Registry

Study & Design

• Study Type: OBSERVATIONAL
• Study Design: Not specified

Primary Outcome Measures

Name	Time	Method
Understanding of the variability, progression , identification and natural history of the manifestations of Pompe disease	maximum 30 years

Trial Locations

Locations (275)

Investigational Site Number : 380017; 🇮🇹 Torino, Italy

Investigational Site Number : 380001; 🇮🇹 Udine, Italy

Investigational Site Number : 392106; 🇯🇵 Sakyo-ku, Kyoto, Japan

Investigational Site Number : 392105; 🇯🇵 Ginowan, Okinawa, Japan

Investigational Site Number : 4000001; 🇯🇴 Amman, Jordan

Investigational Site Number : 153178; 🇰🇷 Yangsan-si, Gyeongsangnam-do, Korea, Republic of

Investigational Site Number : 154148; 🇰🇷 Yangsan, Gyeongsangnam-do, Korea, Republic of

Investigational Site Number : 153180; 🇰🇷 Seoul, Seoul-teukbyeolsi, Korea, Republic of

Investigational Site Number : 153196; 🇰🇷 Seoul, Seoul-teukbyeolsi, Korea, Republic of

Investigational Site Number : 153176; 🇰🇷 Seoul, Seoul-teukbyeolsi, Korea, Republic of

Investigational Site Number : 153191; 🇰🇷 Daejeon, Korea, Republic of

Investigational Site Number : 153225; 🇰🇷 Jeonnam, Korea, Republic of

Investigational Site Number : 380019; 🇮🇹 Napoli, Italy

Investigational Site Number : 380002; 🇮🇹 Padova, Italy

Investigational Site Number : 380003; 🇮🇹 Pavia, Italy

Investigational Site Number : 380015; 🇮🇹 Roma, Italy

Investigational Site Number : 153192; 🇰🇷 Seoul, Korea, Republic of

Investigational Site Number : 764004; 🇹🇭 Bangkok, Thailand

Investigational Site Number : 764001; 🇹🇭 Bangkok, Thailand

Investigational Site Number : 764005; 🇹🇭 Khon Kaen, Thailand

Investigational Site Number : 3480011; 🇭🇺 Pécs, Hungary

Investigational Site Number : 3480012; 🇭🇺 Székesfehérvár, Hungary

Investigational Site Number : 356003; 🇮🇳 Ahmedabad, India

Investigational Site Number : 356001; 🇮🇳 Kolkata, India

Investigational Site Number : 3560004; 🇮🇳 Secunderabad, India

Investigational Site Number : 356002; 🇮🇳 Vellore, India

Investigational Site Number : 360001; 🇮🇩 Jakarta, Indonesia

Investigational Site Number : 3760002; 🇮🇱 Beer Sheva, Israel

Investigational Site Number : 3760001; 🇮🇱 Haifa, Israel

Investigational Site Number : 3760003; 🇮🇱 Tel Aviv, Israel

Investigational Site Number : 380007; 🇮🇹 Milan, Milano, Italy

Investigational Site Number : 380011; 🇮🇹 Padua, Padova, Italy

Investigational Site Number : 380008; 🇮🇹 Brescia, Italy

Investigational Site Number : 380006; 🇮🇹 Cagliari, Italy

Investigational Site Number : 380014; 🇮🇹 Ferrara, Italy

Investigational Site Number : 380005; 🇮🇹 Firenze, Italy

Investigational Site Number : 380004; 🇮🇹 Genova, Italy

Investigational Site Number : 380013; 🇮🇹 Messina, Italy

Investigational Site Number : 380016; 🇮🇹 Milano, Italy

Investigational Site Number : 380009; 🇮🇹 Monza, Italy

Investigational Site Number : 380010; 🇮🇹 Napoli, Italy

Investigational Site Number : 380012; 🇮🇹 Roma, Italy

Investigational Site Number : 151149; 🇰🇷 Seoul, Korea, Republic of

Investigational Site Number : 153212; 🇰🇷 Seoul, Korea, Republic of

Investigational Site Number : 153222; 🇰🇷 Seoul, Korea, Republic of

Investigational Site Number : 154225; 🇰🇼 Kuwait, Kuwait

Investigational Site Number : 4220004; 🇱🇧 Beirut, Lebanon

Investigational Site Number : 4220002; 🇱🇧 Beirut, Lebanon

Investigational Site Number : 458001; 🇲🇾 Jalan Pahang, Malaysia

Investigational Site Number : 458002; 🇲🇾 Kuala Lumpur, Malaysia

Investigational Site Number : 152029; 🇳🇱 Rotterdam, Netherlands

Investigational Site Number : 154264; 🇵🇰 Karachi, Pakistan

Investigational Site Number : 154266; 🇵🇰 Lahore, Pakistan

Investigational Site Number : 608001; 🇵🇭 Manila, Philippines

Investigational Site Number : 150575; 🇵🇱 Warszawa, Poland

Investigational Site Number : 620008; 🇵🇹 Coimbra, Portugal

Investigational Site Number : 620006; 🇵🇹 Lisboa, Portugal

Investigational Site Number : 154099; 🇷🇴 Bucuresti, Romania

Investigational Site Number : 643002; 🇷🇺 Moscow, Russian Federation

Investigational Site Number : 682004; 🇸🇦 Makkah, Saudi Arabia

Investigational Site Number : 682001; 🇸🇦 Qatif, Saudi Arabia

Investigational Site Number : 6880001; 🇷🇸 Belgrade, Serbia

Investigational Site Number : 702001; 🇸🇬 Singapore, Singapore

Investigational Site Number : 703001; 🇸🇰 Bratislava, Slovakia

Investigational Site Number : 154093; 🇨🇳 Chiayi, Taiwan

Investigational Site Number : 152152; 🇨🇳 Hualian, Taiwan

Investigational Site Number : 152246; 🇨🇳 Kaohsiung City, Taiwan

Investigational Site Number : 152244; 🇨🇳 Kaohsiung, Taiwan

Investigational Site Number : 151534; 🇨🇳 New Taipei City, Taiwan

Investigational Site Number : 151500; 🇨🇳 Putz City, Chia-yi, Taiwan

Investigational Site Number : 151181; 🇨🇳 Taichung, Taiwan

Investigational Site Number : 151179; 🇨🇳 Taichung, Taiwan

Investigational Site Number : 153248; 🇨🇳 Tainan City, Taiwan

Investigational Site Number : 152153; 🇨🇳 Tainan City, Taiwan

Investigational Site Number : 151182; 🇨🇳 Taipei City, Taiwan

Investigational Site Number : 152321; 🇨🇳 Taipei, Taiwan

Investigational Site Number : 152226; 🇨🇳 Taipei, Taiwan

Investigational Site Number : 153158; 🇨🇳 Taoyuan City, Taiwan

Investigational Site Number : 764002; 🇹🇭 Bangkok, Thailand

Investigational Site Number : 764003; 🇹🇭 Bangkok, Thailand

Investigational Site Number : 151340; 🇬🇧 Cambridge, Cambridgeshire, United Kingdom

Investigational Site Number : 152287; 🇬🇧 Birmingham, England, United Kingdom

Investigational Site Number : 151646; 🇬🇧 London, London, City Of, United Kingdom

Investigational Site Number : 150303; 🇬🇧 London, London, City Of, United Kingdom

Investigational Site Number : 154240; 🇬🇧 Birmingham, United Kingdom

Investigational Site Number : 152334; 🇬🇧 Cardiff, United Kingdom

Investigational Site Number : 152156; 🇬🇧 Glasgow, United Kingdom

Investigational Site Number : 151123; 🇬🇧 London, United Kingdom

Investigational Site Number : 150455; 🇬🇧 Manchester, United Kingdom

Investigational Site Number : 152087; 🇬🇧 Newcastle, United Kingdom

Investigational Site Number : 150964; 🇬🇧 Salford, United Kingdom

Investigational Site Number : 154212; 🇻🇳 Hanoi, Vietnam

Investigational Site Number : 704002; 🇻🇳 Ho Chi Minh City, Vietnam

University Alabama at Birmingham- Site Number : 840106; 🇺🇸 Birmingham, Alabama, United States

Barrow Neurological Institute- Site Number : 840087; 🇺🇸 Phoenix, Arizona, United States

Phoenix Children's Hospital- Site Number : 840003; 🇺🇸 Phoenix, Arizona, United States

University of Arizona- Site Number : 840015; 🇺🇸 Tucson, Arizona, United States

Arkansas Childrens Hospital- Site Number : 840109; 🇺🇸 Little Rock, Arkansas, United States

University of Arkansas for Medical Sciences- Site Number : 840113; 🇺🇸 Little Rock, Arkansas, United States

University of California at Irvine- Site Number : 840036; 🇺🇸 Irvine, California, United States

Loma Linda University- Genetics- Site Number : 840070; 🇺🇸 Loma Linda, California, United States

Southern California Permanente Medical Group- Site Number : 840108; 🇺🇸 Los Angeles, California, United States

USC Health Sciences Center Dept of Genetics- Site Number : 840082; 🇺🇸 Los Angeles, California, United States

Children's Hospital Oakland- Site Number : 840029; 🇺🇸 Oakland, California, United States

Children's Hospital of Orange County- Site Number : 840074; 🇺🇸 Orange, California, United States

UC Davis MIND Institute- Site Number : 840010; 🇺🇸 Sacramento, California, United States

Loma Linda University Children's Hospital- Site Number : 840117; 🇺🇸 San Bernardino, California, United States

University of California at San Diego- Site Number : 840007; 🇺🇸 San Diego, California, United States

University of California at San Francisco- Site Number : 840051; 🇺🇸 San Francisco, California, United States

Stanford University Pediatrics- Site Number : 840021; 🇺🇸 Stanford, California, United States

Children's Hospital Colorado - Aurora- Site Number : 840069; 🇺🇸 Aurora, Colorado, United States

Yale - Site Number : 840047; 🇺🇸 New Haven, Connecticut, United States

Children's National Medical Center- Site Number : 840067; 🇺🇸 Washington, District of Columbia, United States

University of Florida College of Medicine- Site Number : 840012; 🇺🇸 Gainesville, Florida, United States

University of Florida Pediatrics Genetics- Site Number : 840121; 🇺🇸 Jacksonville, Florida, United States

The Atwal Clinic- Site Number : 840112; 🇺🇸 Jacksonville, Florida, United States

University Of Miami SOM- Site Number : 840006; 🇺🇸 Miami, Florida, United States

University of Florida-Genetics- Site Number : 840096; 🇺🇸 Tampa, Florida, United States

Emory University School of Medicine- Human Genetics- Site Number : 840060; 🇺🇸 Decatur, Georgia, United States

University of Colorado at Denver Genetics- Site Number : 840068; 🇺🇸 Aurora, Illinois, United States

Ann and Robert Lurie Children's Hospital- Site Number : 840011; 🇺🇸 Chicago, Illinois, United States

Ann and Robert Lurie Children's Hospital- Site Number : 840013; 🇺🇸 Chicago, Illinois, United States

Rush University Medical Center Genetics- Site Number : 840079; 🇺🇸 Chicago, Illinois, United States

Indianapolis University School of Medicine- Site Number : 840027; 🇺🇸 Indianapolis, Indiana, United States

University of Iowa- Site Number : 840032; 🇺🇸 Iowa City, Iowa, United States

University of Kansas Medical Center- Site Number : 840020; 🇺🇸 Kansas City, Kansas, United States

University of Louisville- Genetics- Site Number : 840030; 🇺🇸 Louisville, Kentucky, United States

Ochsner Medical Center - Site Number : 840120; 🇺🇸 New Orleans, Louisiana, United States

Maine Medical Center Pediatrics- Site Number : 840064; 🇺🇸 Portland, Maine, United States

John Hopkins- Site Number : 840044; 🇺🇸 Baltimore, Maryland, United States

Massachusetts General Hospital-Genetics- Site Number : 840062; 🇺🇸 Boston, Massachusetts, United States

Infusion Associates- Site Number : 840050; 🇺🇸 Grand Rapids, Michigan, United States

Boston Children's Hospital- Site Number : 840092; 🇺🇸 Boston, Massachusetts, United States

Baystate Health- Site Number : 840002; 🇺🇸 Springfield, Massachusetts, United States

University of Michigan Pediatrics- Site Number : 840107; 🇺🇸 Ann Arbor, Michigan, United States

Children's Hospital of Michigan- Site Number : 840066; 🇺🇸 Detroit, Michigan, United States

Spectrum for Health- Site Number : 840019; 🇺🇸 Grand Rapids, Michigan, United States

Children's Health Care- Site Number : 840114; 🇺🇸 Minneapolis, Minnesota, United States

Children's Hospital and Clinics of Minnesota- Site Number : 840046; 🇺🇸 Minneapolis, Minnesota, United States

University of Minnesota Medical Center Pediatrics- Site Number : 840035; 🇺🇸 Minneapolis, Minnesota, United States

University of Minnesota Medical Center Pediatrics- Site Number : 840076; 🇺🇸 Minneapolis, Minnesota, United States

University of Missouri Health System Department of Genetics- Site Number : 840031; 🇺🇸 Columbia, Missouri, United States

Children's Mercy Hospital- Pediatrics- Site Number : 840063; 🇺🇸 Kansas City, Missouri, United States

Washington University of St. Louis- Site Number : 840100; 🇺🇸 Saint Louis, Missouri, United States

University of Nebraska Medical Center- Pediatrics- Site Number : 840084; 🇺🇸 Omaha, Nebraska, United States

Children's Specialty Center of Nevada- Site Number : 840008; 🇺🇸 Las Vegas, Nevada, United States

Cooper Health Center- Site Number : 840098; 🇺🇸 Camden, New Jersey, United States

Hackensack University Medical Center- Site Number : 840101; 🇺🇸 Hackensack, New Jersey, United States

Atlantic Health System- Site Number : 840099; 🇺🇸 Morristown, New Jersey, United States

St. Peter's University Hospital- Site Number : 840016; 🇺🇸 New Brunswick, New Jersey, United States

St. Joseph's Children's Hospital- Site Number : 840057; 🇺🇸 Paterson, New Jersey, United States

Northwell Health- Site Number : 840102; 🇺🇸 Manhasset, New York, United States

New York University School Of Medicine- Site Number : 840040; 🇺🇸 New York, New York, United States

Metropolitan Hospital Center- Site Number : 840110; 🇺🇸 New York, New York, United States

Mt. Sinai School of Medicine- Site Number : 840005; 🇺🇸 New York, New York, United States

University of Rochester Medical Center SOM- Site Number : 840105; 🇺🇸 Rochester, New York, United States

State University of New York- Site Number : 840052; 🇺🇸 Syracuse, New York, United States

New York Medical College- Site Number : 840039; 🇺🇸 Valhalla, New York, United States

Investigational Site Number : 152380; 🇨🇳 Beijing, China

Carolinas Medical Center Hospital- Site Number : 840065; 🇺🇸 Charlotte, North Carolina, United States

Duke University Medical Center Genetics Dept- Site Number : 840037; 🇺🇸 Durham, North Carolina, United States

Cincinnati Children's Hospital-Genetics- Site Number : 840041; 🇺🇸 Cincinnati, Ohio, United States

University Hospitals Cleveland Medical Center- Site Number : 840119; 🇺🇸 Cleveland, Ohio, United States

Cleveland Clinic Foundation Pediatrics- Site Number : 840048; 🇺🇸 Cleveland, Ohio, United States

Nationwide Children's Hospital- Site Number : 840091; 🇺🇸 Columbus, Ohio, United States

LSD Data Registry Site LLC- Site Number : 840094; 🇺🇸 Dublin, Ohio, United States

Investigational Site Number : 250014; 🇫🇷 Toulouse, France

Oregon Health & Sciences University- Site Number : 840080; 🇺🇸 Portland, Oregon, United States

Oregon Health and Science University- Site Number : 840095; 🇺🇸 Portland, Oregon, United States

Oregon Health and Scinece University- Site Number : 840038; 🇺🇸 Portland, Oregon, United States

Penn Hershey Medical Center- Site Number : 840061; 🇺🇸 Hershey, Pennsylvania, United States

Children's Hospital of Philadelphia HUP Medical Genetics- Site Number : 840089; 🇺🇸 Philadelphia, Pennsylvania, United States

Children's Hospital of Philadelphia- Site Number : 840034; 🇺🇸 Philadelphia, Pennsylvania, United States

UPMC- Site Number : 840014; 🇺🇸 Pittsburgh, Pennsylvania, United States

University of Pittsburgh- Site Number : 840023; 🇺🇸 Pittsburgh, Pennsylvania, United States

Rhode Island Hospital Genetics- Site Number : 840053; 🇺🇸 Providence, Rhode Island, United States

Greenwood Genetcs- Site Number : 840055; 🇺🇸 Greenville, South Carolina, United States

Vanderbilt University Hospital-Pediatrics- Site Number : 840049; 🇺🇸 Nashville, Tennessee, United States

Baylor Research Center- Site Number : 840058; 🇺🇸 Dallas, Texas, United States

Cook Children's Health Care System- Site Number : 840024; 🇺🇸 Fort Worth, Texas, United States

University of Utah Department of Medical Genetics- Site Number : 840043; 🇺🇸 Salt Lake City, Utah, United States

University of Virginia School of Medicine-Pediatrics- Site Number : 840078; 🇺🇸 Charlottesville, Virginia, United States

O&O Alpan, LLC- Site Number : 840025; 🇺🇸 Fairfax, Virginia, United States

Children's Hospital of the Kings Daughters- Site Number : 840072; 🇺🇸 Norfolk, Virginia, United States

Seattle Children's Hospital- Site Number : 840028; 🇺🇸 Seattle, Washington, United States

University Of Washington Medical Center- Site Number : 840059; 🇺🇸 Seattle, Washington, United States

Multicare Health System ¿ Mary Bridge Childrens Hospital- Site Number : 840115; 🇺🇸 Tacoma, Washington, United States

Children's Hospital of Wisconsin-Pediatrics- Site Number : 840054; 🇺🇸 Milwaukee, Wisconsin, United States

Investigational Site Number : 152218; 🇦🇷 Caba, Buenos Aires, Argentina

Investigational Site Number : 153194; 🇦🇷 Caba, Buenos Aires, Argentina

Investigational Site Number : 153032; 🇦🇷 Ciudad Autónoma de Buenos Aires, Buenos Aires, Argentina

Investigational Site Number : 036013; 🇦🇺 Westmead, New South Wales, Australia

Investigational Site Number : 151069; 🇦🇺 Westmead, New South Wales, Australia

Investigational Site Number : 154087; 🇦🇺 Brisbane, Queensland, Australia

Investigational Site Number : 152096; 🇦🇺 Brisbane, Queensland, Australia

Investigational Site Number : 151002; 🇦🇺 Adelaide, South Australia, Australia

Investigational Site Number : 151015; 🇦🇺 Murdoch, Western Australia, Australia

Investigational Site Number : 150722; 🇧🇪 Antwerp, Belgium

Investigational Site Number : 154298; 🇧🇪 Bruges, Belgium

Investigational Site Number : 056010; 🇧🇪 Brussels, Belgium

Investigational Site Number : 150684; 🇧🇪 Bruxelles, Belgium

Investigational Site Number : 152072; 🇧🇪 Edegem, Belgium

Investigational Site Number : 152295; 🇧🇪 Gent, Belgium

Investigational Site Number : 153179; 🇧🇪 Gosselies, Belgium

Investigational Site Number : 151668; 🇧🇪 Leuven, Belgium

Investigational Site Number : 152126; 🇧🇪 Leuven, Belgium

Hospital Universitario Walter Cantidio- Site Number : 076011; 🇧🇷 Fortaleza, Ceará, Brazil

Hospital Geral e Maternidade de Cuiabá- Site Number : 076003; 🇧🇷 Cuiabá, Mato Grosso, Brazil

Hospital de Clinicas de Porto Alegre- Site Number : 076008; 🇧🇷 Porto Alegre, Rio Grande Do Sul, Brazil

Hospital das Clinicas da Faculdade de Medicina de Ribeirao Preto- Site Number : 076009; 🇧🇷 Ribeirão Preto, São Paulo, Brazil

Instituto Fernandes Figueira - FIOCRUZ- Site Number : 076001; 🇧🇷 Rio de Janeiro, Brazil

Instituto de Genética e Erros Inatos do Metabolismo- Site Number : 076002; 🇧🇷 São Paulo, Brazil

Núcleo de Gestão em Pesquisa (NGP) - UNIFESP- Site Number : 076012; 🇧🇷 São Paulo, Brazil

Hospital das Clinicas da Faculdade de Medicina da Universidade de Sao Paulo- Site Number : 076004; 🇧🇷 São Paulo, Brazil

Hospital das Clinicas FMUSP- Site Number : 076007; 🇧🇷 São Paulo, Brazil

Investigational Site Number : 100001; 🇧🇬 Sofia, Bulgaria

Investigational Site Number : 124014; 🇨🇦 Calgary, Alberta, Canada

Investigational Site Number : 124002; 🇨🇦 Edmonton, Alberta, Canada

Investigational Site Number : 124010; 🇨🇦 Vancouver, British Columbia, Canada

Investigational Site Number : 124011; 🇨🇦 Vancouver, British Columbia, Canada

Investigational Site Number : 124019; 🇨🇦 Winnipeg, Manitoba, Canada

Investigational Site Number : 124022; 🇨🇦 Moncton, New Brunswick, Canada

Investigational Site Number : 124007; 🇨🇦 Hamilton, Ontario, Canada

Investigational Site Number : 124021; 🇨🇦 London, Ontario, Canada

Investigational Site Number : 124006; 🇨🇦 Toronto, Ontario, Canada

Investigational Site Number : 124004; 🇨🇦 Montreal, Quebec, Canada

Investigational Site Number : 124018; 🇨🇦 Montreal, Quebec, Canada

Investigational Site Number : 124001; 🇨🇦 Sherbrooke, Quebec, Canada

Investigational Site Number : 152002; 🇨🇱 Punta Arenas, Chile

Investigational Site Number : 152001; 🇨🇱 Santiago, Chile

Investigational Site Number : 153202; 🇨🇳 Beijing, China

Investigational Site Number : 153203; 🇨🇳 Beijing, China

Investigational Site Number : 152379; 🇨🇳 Guangzhou, China

Investigational Site Number : 152381; 🇨🇳 Jinan, China

Investigational Site Number : 152356; 🇨🇳 Shanghai, China

Investigational Site Number : 152382; 🇨🇳 Shanghai, China

Investigational Site Number : 170001; 🇨🇴 Bogota, Colombia

Investigational Site Number : 1910001; 🇭🇷 Zagreb, Croatia

Investigational Site Number : 1910002; 🇭🇷 Zagreb, Croatia

Investigational Site Number : 150809; 🇨🇿 Praha 2, Czechia

Investigational Site Number : 151229; 🇩🇰 København Ø, Denmark

Investigational Site Number : 250010; 🇫🇷 Bordeaux, France

Investigational Site Number : 250012; 🇫🇷 Brest, France

Investigational Site Number : 250003; 🇫🇷 BRON Cedex, France

Investigational Site Number : 250007; 🇫🇷 BRON Cedex, France

Investigational Site Number : 250009; 🇫🇷 Caen, France

Investigational Site Number : 250015; 🇫🇷 La Tronche, France

Investigational Site Number : 250008; 🇫🇷 Lille, France

Investigational Site Number : 250002; 🇫🇷 Marseille Cedex 05, France

Investigational Site Number : 250017; 🇫🇷 Nancy, France

Investigational Site Number : 250019; 🇫🇷 Nantes, France

Investigational Site Number : 250005; 🇫🇷 Nice, France

Investigational Site Number : 250011; 🇫🇷 Nîmes, France

Investigational Site Number : 250004; 🇫🇷 Paris, France

Investigational Site Number : 250001; 🇫🇷 Paris, France

Investigational Site Number : 250018; 🇫🇷 St-priest-en-jarez, France

Investigational Site Number : 250016; 🇫🇷 Strasbourg, France

Investigational Site Number : 250006; 🇫🇷 Tours, France

Investigational Site Number : 25013; 🇫🇷 Vannes Cedex, France

Investigational Site Number : 152041; 🇩🇪 Berlin, Germany

Investigational Site Number : 151686; 🇩🇪 Berlin, Germany

Investigational Site Number : 152293; 🇩🇪 Berlin, Germany

Investigational Site Number : 152234; 🇩🇪 Bochum, Germany

Investigational Site Number : 152200; 🇩🇪 Bonn, Germany

Investigational Site Number : 152108; 🇩🇪 Freiburg, Germany

Investigational Site Number : 154150; 🇩🇪 Gießen, Germany

Investigational Site Number : 152045; 🇩🇪 Halle (Saale), Germany

Investigational Site Number : 154215; 🇩🇪 Hamburg, Germany

Investigational Site Number : 150031; 🇩🇪 Mainz, Germany

Investigational Site Number : 152075; 🇩🇪 München, Germany

Investigational Site Number : 152299; 🇩🇪 Münster, Germany

Investigational Site Number : 300001; 🇬🇷 Thessaloniki, Greece

Investigational Site Number : 344001; 🇭🇰 Kowloon, Hong Kong

Investigational Site Number : 3480009; 🇭🇺 Debrecen, Hungary

Investigational Site Number : 3480007; 🇭🇺 Nyíregyháza, Hungary