A Neurophysiological Investigation of the Effectiveness of Web-based Exergaming Platform of Cognitive and Physical Training in Schizophrenic Patients
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 4
- 试验地点
- 1
- 主要终点
- Alterations in functional connectivity properties and on the organization of resting state networks
研究概览
简要总结
Neurophysilogical, neuropsychological evaluation and cognitive and physical training
详细描述
24 sessions (8 weeks, 3 times per week) of cognitive and physical training via computer. Each session consisted of 45 minutes of cognitive traing (BrainHQ platform https://www.brainhq.com/) and 45 minutes of physical training (FitForAll platform https://www.fitforall.gr/play/app/). Cognitive training included memory, attention, velocity, intelligence etc. Physical training included aerobic, strength flexibility and other excercises. All evaluations were performed 1-14 before the initiation of the interventions and 1-14 after their completion. Neurophysiological evaluation consisted of EEG with the use of 128 electrode-machine and the protocol included 5 minuted of eyes closed and 5 minutes of eyes open. Neuropsychological evaluation included Trail Making Test (A & B), Verbal Fluency, Stroop test, Wechsler Memory - Cubes (visuospatial), MoCA, FAB (Screening for frontal damage) and Eyes Test (Theory of Mind). Also, the physical condition evaluation included 6-Minute Walking Distance (6MWD), ΒΜΙ, HandGrip Strength Test, Short Physical Performance Battery Protocol.
研究设计
- 研究类型
- Interventional
- 分配方式
- Na
- 干预模型
- Single Group
- 主要目的
- Health Services Research
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 65 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •a diagnosis of schizophrenia disorder according to ICD10 criteria
- •clinically stable patients (no recent change in psychotropic medication except benzodiazepines)
- •sufficient acculturation and fluency in Greek language
- •assent of the attending physician for participation in the study
排除标准
- •co-morbidity with neurological disorders (e.g.epilepsy) or head injury
- •a pathological or other somatic disorder that contraindicate physical exercise
- •alcoholism and substance abuse within the previous 3 months (except caffeine and tobacco)
- •abstainance from intervention for more than 12 days
- •cognitive decline
- •treated with Benzodiazepine
结局指标
主要结局
Alterations in functional connectivity properties and on the organization of resting state networks
时间窗: 3 months
Alterations in functional connectivity properties and on the organization of resting state networks quantified through graph theory tools. These measures would be measured through high-density electroencephalographic (EEG) evaluation and reconstruction of cortical activity.
次要结局
- Reaction time(2 months)
- Visual attention and task switching(2 months)
- Generic cogntive impairment(2 months)
- Memory(2 months)
- Executive function(2 months)
- Theory of mind(2 months)
- Depressive syndromes(2 months)
- Verbal fluency(2 months)
- Physical fitness(2 months)
研究者
Panos Bamidis
Associate Professor
Aristotle University Of Thessaloniki