Prospective Study of the Effects of Helicobacter Pylori Eradication on Renal Functions and Proteinuria in Patients With Membranous Nephropathy
试验速览
- 阶段
- 不适用
- 状态
- 已完成
- 入组人数
- 70
- 试验地点
- 1
- 主要终点
- Daily proteinuria levels after Helicobacter Pylori eradication treatment
研究概览
简要总结
Membranous nephropathy (MN) may also be secondary to many other diseases (e.g., infections, drugs, neoplasms and autoimmune diseases). In this study, the presence of Helicobacter Pylori (H. pylori) antigen was investigated in renal tissue from needle biopsy samples, and the prevalence of H. pylori infection and the effects of H. pylori eradication on proteinuria level in patients with MN will be investigated.
详细描述
Membranous nephropathy (MN) is a common cause of nephrotic syndrome in adults. It is thought to be mainly a primary or idiopathic form; however, it may also be secondary to many other diseases (e.g., infections, drugs, neoplasms and autoimmune diseases). In this study, the presence of Helicobacter Pylori antigen was investigated in renal tissue from needle biopsy samples, and the prevalence of H. pylori infection and the effects of H. pylori eradication on proteinuria level in patients with MN will be investigated.
研究设计
- 研究类型
- Interventional
- 分配方式
- Randomized
- 干预模型
- Parallel
- 主要目的
- Supportive Care
- 盲法
- None
入排标准
- 年龄范围
- 18 Years 至 70 Years（Adult, Older Adult）
- 性别
- All
- 接受健康志愿者
- 否
入选标准
- •Age between 18-70 years
- •Nondiabetic patients
- •Patients with primary glomerulonephritis
- •Clinical diagnosis of membranous nephropathy, IgA nephropathy or focal segmental glomerulosclerosis confirmed by biopsy
- •Glomerular filtration rate > 30 mL/min
- •Patients who did not receive Helicobacter pylori eradication therapy within the last three months before enrollment in study
排除标准
- •Patients with secondary glomerulonephritis
- •Glomerular filtration rate < 30 mL/min
- •Patients who received Helicobacter pylori eradication therapy within the last three months before enrollment in study
- •Patients with a history of gastric surgery
- •Patients without an informed consent
研究组 & 干预措施
Membranous nephropathy
Patients with primary membranous nephropathy diagnosed by biopsy
干预措施: lansoprazole, amoxicillin, clarithromycin (Drug)
IgA nephropathy
Patients with IgA nephropathy diagnosed by biopsy
干预措施: lansoprazole, amoxicillin, clarithromycin (Drug)
Focal segmental glomerulosclerosis
Patients with primary focal segmental glomerulosclerosis diagnosed by biopsy
干预措施: lansoprazole, amoxicillin, clarithromycin (Drug)
结局指标
主要结局
Daily proteinuria levels after Helicobacter Pylori eradication treatment
时间窗: 6 months
次要结局
- Glomerular filtration rate(6 months)
- Serum creatinine level(6 months)